External Email - Use Caution        

Dear Wayne,
We have an idea of what the problem might be and will look into it soon.
Cheers,
/Eugenio


--
Juan Eugenio Iglesias
ERC Senior Research Fellow
Translational Imaging Group
University College London
http://www.jeiglesias.com
http://cmictig.cs.ucl.ac.uk/


From: <freesurfer-boun...@nmr.mgh.harvard.edu> on behalf of Wayne Su 
<wayne...@gmail.com>
Reply-To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
Date: Wednesday, 2 May 2018 at 18:39
To: "freesurfer@nmr.mgh.harvard.edu" <freesurfer@nmr.mgh.harvard.edu>
Subject: [Freesurfer] kvlGEMSMatlab error: search direction is not a descent 
direction


        External Email - Use Caution
Hello FreeSurfer Developers,

I'm attempting to run longitudinal segmentation of hippocampal subfields by 
using the development version of FreeSurfer, but for some of my subjects I get 
the following error:

*******************
 Global iteration 3
*******************

   ***** Estimating subject-specific atlas *****
L-BFGS
Verbose: 0
MaximalDeformationStopCriterion: 1e-10
LineSearchMaximalDeformationIntervalStopCriterion: 1e-10
MaximumNumberOfIterations: 1000
BFGS-MaximumMemoryLength: 12
Subject atlas deformation, step 1 of 400
Did one deformation step of max. 0.38685 voxels in 7.733 seconds

minLogLikelihoodTimesPrior =

   1.0297e+05

Subject atlas deformation, step 2 of 400
Error using kvlGEMSMatlab
/autofs/space/panamint_005/users/iglesias/software/freesurfer/GEMS2/kvlAtlasMeshDeformationOptimizer.cxx:327:
itk::ERROR: AtlasMeshDeformationLBFGSOptimizer(0x2b53b9427df0): search 
direction is not a descent direction!

Error in kvlStepOptimizer (line 11)
Error in SegmentSubfieldsT1Longitudinal (line 1169)


Does anyone have any thoughts on how to trouble-shoot this one?

1) FreeSurfer version: freesurfer-x86_64-unknown-linux-gnu-dev-20180426
2) Platform: CentOS Linux release 7.4.1708 (Core)
3) uname -a: Linux bcmhari-hpc12 3.10.0-327.el7.x86_64 #1 SMP Thu Nov 19 
22:10:57 UTC 2015 x86_64 x86_64 x86_64 GNU/Linux



Thanks,
Wayne
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