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Hello FreeSurfer Developers,
> 
> I'm attempting to run longitudinal segmentation of hippocampal subfields by
> using the development version of FreeSurfer, but for some of my subjects I get
> the following error:
>  
> *******************
>  Global iteration 3
> *******************
>  
>    ***** Estimating subject-specific atlas *****
> L-BFGS
> Verbose: 0
> MaximalDeformationStopCriterion: 1e-10
> LineSearchMaximalDeformationIntervalStopCriterion: 1e-10
> MaximumNumberOfIterations: 1000
> BFGS-MaximumMemoryLength: 12
> Subject atlas deformation, step 1 of 400
> Did one deformation step of max. 0.38685 voxels in 7.733 seconds
> 
> minLogLikelihoodTimesPrior =
> 
>    1.0297e+05
> 
> Subject atlas deformation, step 2 of 400
> Error using kvlGEMSMatlab
> /autofs/space/panamint_005/users/iglesias/software/freesurfer/GEMS2/kvlAtlasMe
> shDeformationOptimizer.cxx:327:
> itk::ERROR: AtlasMeshDeformationLBFGSOptimizer(0x2b53b9427df0): search
> direction is not a descent direction!
> 
> Error in kvlStepOptimizer (line 11)
> Error in SegmentSubfieldsT1Longitudinal (line 1169)
> 
> 
> Does anyone have any thoughts on how to trouble-shoot this one?
> 
> 1) FreeSurfer version: freesurfer-x86_64-unknown-linux-gnu-dev-20180426
> 2) Platform: CentOS Linux release 7.4.1708 (Core)
> 3) uname -a: Linux bcmhari-hpc12 3.10.0-327.el7.x86_64 #1 SMP Thu Nov 19
> 22:10:57 UTC 2015 x86_64 x86_64 x86_64 GNU/Linux
> 
> 
> 
> Thanks,
> Wayne

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