I would add that my guess is the FLAIR is helpful up to about 1.25-1.5mm 
thickest dimension

cheers
Bruce


On Wed, 28 Feb 2018, Glasser, Matthew wrote:

> The trouble with highly anisotropic resolutions is that your resolution is
> only as good as your worst axis for the convoluted cerebral cortex.  0.8mm
> or better would be optimal given a minimum cortical thickness of 1.6mm.
>
> You can always try with what you have and see if it is net beneficial or
> not.
>
> Peace,
>
> Matt.
>
> On 2/28/18, 12:40 PM, "freesurfer-boun...@nmr.mgh.harvard.edu on behalf of
> Christopher Markiewicz" <freesurfer-boun...@nmr.mgh.harvard.edu on behalf
> of markiew...@stanford.edu> wrote:
>
>> Hi all,
>>
>> I wonder if people have any data (or anecdotes - I'm not picky) with
>> regard to how high of resolution T2w or FLAIR images need to be in order
>> to be useful for FreeSurfer's pial refinement. I've seen a couple threads
>> suggesting the optimal is ~1mm isotropic, and that thick slice (1x1x5
>> mm^3) FLAIR images could be tried, but might hurt more than help, and I'm
>> wondering if there's a suboptimal-but-still-useful range somewhere in
>> between.
>>
>> For the record, this isn't a question of what scan parameters are
>> recommended, but rather is in the context of data that's already been
>> collected, which I would like to preprocess as well as possible.
>>
>> So, at what resolutions would you recommend (a) completely ignoring
>> T2w/FLAIR images; (b) including T2w/FLAIR images that pass QC; (c) trying
>> and seeing? Do these answers change at all with T1w resolution?
>>
>> --
>> Chris Markiewicz
>> Center for Reproducible Neuroscience
>> Stanford University
>>
>>
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