Dear Freesurfer developers,
I'm running a standard cortical thickness analysis between 2 patient
groups (patients with schizophrenia with hallucinations (H) vs. patients
with schizophrenia without hallucinations (NH)). I'm looking at the main
effect of group (H vs. NH), while controlling for sex and age. I'm using
default QDEC parameters (DODS, fwhm 10). I'm wondering whether I should
demean age (ie., demeaned = age - mean age), as this has been
recommended by FSL for VBM. I'm asking because whether or not I demean
changes my results in QDEC. Moreover, I'm wondering whether it makes any
difference to include age (demeaned or not) as a nuisance factor or a
covariate. I've attached my qdec table (I'm not including both age and
demeaned age in my model, I've just put them both in for viewing
purposes. Age_MC is demeaned age).
Thanks in advance, I hugely appreciate your insight.
Kindest regards,
Colleen
--
Colleen Rollins, PhD Candidate
Department of Psychiatry
University of Cambridge
Herchel Smith Building, Robinson Way, Cambridge CB2 0SZ
GroupDescriptorFile 1
Class NH_Male
Class NH_Female
Class H_Male
Class H_Female
Variables Age
Input H_BMN001-002 H_Male 32
Input H_BMN001-003 H_Male 19
Input H_BMN001-006 H_Male 26
Input H_BMN001-015 H_Male 30
Input H_BMN001-040 H_Female 28
Input H_BMN001-041 H_Female 20
Input H_BMN001-042 H_Male 25
Input H_BMN001-043 H_Male 20
Input H_BMN001-044 H_Male 25
Input H_BMN001-046 H_Male 21
Input H_BMN001-055 H_Male 26
Input H_BMN001-056 H_Male 22
Input H_BMN001-057 H_Male 32
Input H_BMN001-058 H_Male 29
Input H_BMN001-059 H_Female 26
Input H_BMN001-060 H_Male 23
Input H_BMN001-061 H_Male 21
Input H_BMN001-062 H_Male 27
Input H_BMN001-065 H_Male 26
Input H_BMN001-067 H_Male 26
Input H_BMN001-068 H_Male 29
Input H_BMN001-069 H_Female 18
Input H_BMN001-071 H_Male 23
Input H_BMN001-073 H_Male 23
Input H_BMN001-077 H_Male 23
Input H_BMN001-079 H_Male 29
Input H_BMN001-080 H_Male 25
Input H_BMN001-082 H_Female 20
Input H_BMN001-084 H_Male 23
Input H_BMN001-085 H_Male 35
Input H_BMN001-087 H_Male 25
Input H_BMN001-093 H_Female 25
Input H_BMN001-105 H_Male 22
Input H_BMN001-109 H_Male 18
Input H_BMN001-115 H_Male 35
Input H_BMN001-120 H_Female 20
Input H_BMN001-122 H_Male 25
Input H_BMN001-123 H_Male 23
Input H_BMN001-134 H_Male 23
Input H_BMN002-011 H_Male 24
Input H_BMN002-012 H_Male 26
Input H_BMN002-025 H_Male 36
Input H_BMN002-026 H_Male 18
Input H_BMN002-027 H_Female 17
Input H_BMN002-028 H_Female 29
Input H_BMN002-029 H_Female 33
Input H_BMN002-041 H_Male 23
Input H_BMN002-043 H_Female 23
Input H_BMN002-047 H_Female 17
Input H_BMN002-059 H_Male 23
Input H_BMN002-061 H_Male 25
Input H_BMN002-062 H_Female 25
Input H_BMN002-063 H_Male 33
Input H_BMN002-064 H_Female 27
Input H_BMN002-065 H_Female 23
Input H_BMN002-068 H_Female 25
Input H_BMN002-069 H_Male 28
Input H_BMN002-070 H_Female 31
Input H_BMN002-072 H_Male 29
Input H_BMN002-073 H_Male 25
Input H_BMN002-074 H_Male 27
Input H_BMN002-075 H_Male 26
Input H_BMN002-078 H_Male 30
Input H_BMN002-079 H_Female 23
Input H_BMN002-080 H_Female 21
Input H_BMN002-081 H_Male 34
Input H_BMN002-082 H_Female 31
Input H_BMN002-085 H_Female 30
Input H_BMN002-087 H_Female 35
Input H_BMN002-088 H_Male 22
Input H_BMN002-089 H_Male 24
Input H_BMN003-001 H_Male 22
Input H_BMN003-012 H_Male 21
Input H_BMN003-015 H_Male 27
Input H_BMN003-037 H_Female 34
Input H_BMN003-049 H_Male 21
Input H_BMN003-050 H_Female 31
Input H_BMN003-051 H_Male 24
Input H_BMN003-052 H_Female 35
Input H_BMN003-053 H_Female 25
Input H_BMN003-054 H_Male 28
Input H_BMN003-055 H_Male 19
Input H_BMN003-056 H_Female 31
Input H_BMN004-001 H_Male 29
Input H_BMN004-005 H_Female 26
Input H_BMN004-006 H_Male 36
Input H_BMN004-007 H_Male 21
Input H_BMN004-008 H_Female 24
Input H_BMN004-009 H_Female 23
Input H_BMN004-010 H_Female 17
Input H_BMN004-027 H_Male 18
Input H_BMN004-028 H_Male 36
Input H_BMN004-029 H_Male 29
Input H_BMN004-051 H_Male 24
Input H_BMN004-063 H_Male 24
Input H_BMN004-065 H_Male 33
Input H_BMN004-066 H_Female 36
Input H_BMN004-067 H_Male 20
Input H_BMN004-068 H_Male 16
Input H_BMN004-069 H_Male 17
Input H_BMN004-070 H_Male 19
Input H_BMN004-071 H_Male 25
Input H_BMN004-072 H_Male 24
Input H_BMN004-073 H_Male 19
Input H_BMN004-074 H_Male 20
Input H_BMN004-075 H_Female 33
Input H_BMN004-077 H_Male 24
Input H_BMN004-078 H_Male 23
Input H_BMN005-012 H_Male 23
Input H_BMN005-023 H_Male 32
Input H_BMN005-058 H_Male 27
Input H_BMN005-069 H_Male 29
Input H_BMN005-072 H_Male 18
Input H_BMN006-035 H_Male 28
Input H_BMN006-037 H_Male 24
Input H_BMN006-038 H_Male 23
Input H_BMN006-039 H_Male 24
Input H_BMN006-040 H_Female 32
Input H_BMN006-041 H_Male 18
Input H_BMN006-042 H_Male 22
Input H_BMN006-076 H_Male 27
Input H_BMN006-077 H_Female 21
Input H_BMN006-094 H_Male 29
Input H_BMN006-096 H_Male 24
Input H_BMN006-097 H_Female 21
Input H_BMN006-099 H_Male 20
Input H_BMN006-101 H_Male 25
Input H_BMN006-102 H_Female 27
Input H_BMN006-103 H_Male 24
Input H_BMN006-104 H_Male 30
Input H_BMN007-001 H_Male 29
Input H_BMN007-013 H_Male 34
Input H_BMN007-025 H_Male 21
Input H_BMN007-026 H_Male 29
Input H_BMN007-028 H_Male 19
Input H_BMN007-029 H_Male 21
Input H_BMN007-033 H_Male 23
Input H_BMN007-034 H_Male 32
Input H_BMN007-035 H_Female 28
Input H_BMN007-048 H_Male 21
Input NH_BMN001-013 NH_Female 21
Input NH_BMN001-029 NH_Male 35
Input NH_BMN001-047 NH_Male 25
Input NH_BMN001-048 NH_Male 24
Input NH_BMN001-063 NH_Female 32
Input NH_BMN001-064 NH_Female 34
Input NH_BMN001-066 NH_Female 40
Input NH_BMN001-070 NH_Male 22
Input NH_BMN001-072 NH_Male 26
Input NH_BMN001-074 NH_Male 32
Input NH_BMN001-075 NH_Male 29
Input NH_BMN001-090 NH_Male 22
Input NH_BMN001-095 NH_Female 19
Input NH_BMN001-107 NH_Male 19
Input NH_BMN001-108 NH_Male 24
Input NH_BMN002-001 NH_Female 24
Input NH_BMN002-013 NH_Female 23
Input NH_BMN002-023 NH_Male 30
Input NH_BMN002-024 NH_Female 18
Input NH_BMN002-042 NH_Male 23
Input NH_BMN002-045 NH_Male 21
Input NH_BMN002-060 NH_Male 20
Input NH_BMN002-086 NH_Female 18
Input NH_BMN002-090 NH_Male 24
Input NH_BMN002-101 NH_Male 37
Input NH_BMN002-102 NH_Female 32
Input NH_BMN003-014 NH_Male 33
Input NH_BMN003-036 NH_Male 27
Input NH_BMN004-040 NH_Female 18
Input NH_BMN004-064 NH_Male 32
Input NH_BMN004-076 NH_Female 20
Input NH_BMN005-021 NH_Male 29
Input NH_BMN005-046 NH_Female 26
Input NH_BMN005-047 NH_Male 30
Input NH_BMN005-076 NH_Male 35
Input NH_BMN005-083 NH_Female 30
Input NH_BMN006-043 NH_Male 37
Input NH_BMN006-100 NH_Male 29
Input NH_BMN007-002 NH_Male 28
Input NH_BMN007-023 NH_Male 22
Input NH_BMN007-024 NH_Male 29
Input NH_BMN007-027 NH_Male 26
Input NH_BMN007-030 NH_Male 23
Input NH_BMN007-032 NH_Male 20
Input NH_BMN007-036 NH_Male 19
Input NH_BMN007-037 NH_Male 22
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