You can do the comparison, but the interpretation is difficult. If you 
see a difference, how do you know it is not due to the scanner? There's 
not much you can do ...


On 09/29/2016 02:54 PM, Martin Juneja wrote:
> Hello FS experts,
>
> I have a data set of 20 subjects (patients) collected at location-1 
> with 3T Siemens scanner. Also, I have a set of age-matched 20 subjects 
> (controls) collected at location-2 with 3T Siemens scanner.
>
> I am interested in comparing cortical thickness between controls and 
> patients using FreeSurfer but I am not sure if I can do that since I 
> have both the data sets collected at two different locations.
>
> I would really appreciate any inputs on this.
>
> I tried to find some papers on scanner differences but all I could 
> find was between 1.5 T vs 3T or 3T vs 7T. Is there any special 
> covariates I need to define for this purpose (if so then at which step 
> during analysis?) or is it not possible at all?
>
> Thanks.
>
>
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> Freesurfer@nmr.mgh.harvard.edu
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