Would any member of the FreeSurfer team be able to help with this question?

I would like to use the FreeSurfer software to delineate white matter 
hyperintensities. I have processed my T1 images using the recon-all command, 
and in the aseg.stat file there is a value for WM hypointensities.

Is there an alternate stream/ FreeSurfer algorithm that exists for the 
processing of T2w FLAIR images for WM hyperintensities?

Thanks,
Navena


________________________________
From: freesurfer-boun...@nmr.mgh.harvard.edu 
<freesurfer-boun...@nmr.mgh.harvard.edu> on behalf of Martin Reuter 
<mreu...@nmr.mgh.harvard.edu>
Sent: May 17, 2016 1:32 PM
To: Freesurfer support list
Subject: [Freesurfer] WM Hyperintensities

Hi Navena,

I am the wrong person to answer questions about the WM lesion stream. I think 
the one that is available in FreeSurfer is only based on T1 images, but a 
prototype of a better stream exists, that can incorporate different modalities.

Best, Martin

P.S. Changed the subject, to reflect that this is not a longitudinal question 
any more.

On 05/17/2016 12:37 PM, Navena Rebecca Lingum wrote:
Dear Martin,

Thank you kindly for your prompt response.

I am actually having difficulties with the delineation of White Matter 
Hyperintensities at a single time point. I apologize if my question is 
redundant and perhaps an answer to it is already mentioned elsewhere.

As it stands, I am finding it difficult to understand the exact "pipeline" of 
commands necessary to perform this segmentation and accurate delineation of 
WMH. I have ran the recon -all command on my T1w images, but I suspect a proper 
segmentation of WMH would require a T2w Flair (which I have). How do I go about 
combining the preprocessing data produced by FreeSurfer with my T2w images to 
produce a WMH mask/volume/stats?

Any help on the matter is much appreciated!

Kindly,
Navena Lingum


On May 16, 2016, at 4:24 PM, Martin Reuter 
<mreu...@nmr.mgh.harvard.edu<mailto:mreu...@nmr.mgh.harvard.edu>> wrote:

Hi Navena,

There is currently no dedicated stream for longitudinal WM abnormalities (in 
the sense of joint estimation and modeling). You can, however, make use of the 
longitudinal stream and it's increase reliability - e.g it is working in the 
same space across time, which should help get more reliable estimates.

Best, Martin

On 05/16/2016 01:47 PM, Navena Rebecca Lingum wrote:
Dear FreeSurfer experts,

My colleagues and I would like to use FreeSurfer to perform a longitudinal 
analysis of white matter hyperintensities. Is there an additional add-on for 
the software to perform this analysis or can this analysis be performed using 
the recon-all command?

Navena Lingum



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--
Martin Reuter, PhD
Assistant Professor of Radiology, Harvard Medical School
Assistant Professor of Neurology, Harvard Medical School
A.A.Martinos Center for Biomedical Imaging
Massachusetts General Hospital
Research Affiliate, CSAIL, MIT
Phone: +1-617-724-5652
Web  : http://reuter.mit.edu
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