There is not a difference between mris_fwhm and mri_surf2surf. 
mris_smooth smoothes the xyz coordinates of the vertices of a surface 
(the others smooth an overlay).

On 05/05/2016 03:53 PM, Ajay Kurani wrote:
> Hi Doug,
>    Thanks for the quick reply.
>
> Is there a difference  from qcache/mris_fwhm with mris_smooth and 
> mri_surf2surf -fwhm ?  If so,  which is recommended for cortical 
> thickness analysis?
>
> Thanks,
> Ajay
>
> On Wed, May 4, 2016 at 11:18 PM, Ajay Kurani <dr.ajay.kur...@gmail.com 
> <mailto:dr.ajay.kur...@gmail.com>> wrote:
>
>     Hi Freesurfer Experts,
>        Just as a followup through my reading i've come across posts
>     which use qcache, mris_fwhm, mri_surf2surf or mris_smooth for
>     smoothing.  For my cortical thickness analysis I would like to
>     smooth all of my rh/lh.thickness.fsaverage.mgh files for each
>     subject in order to run a group analysis.  After finding regions
>     of difference, I would then like to use the ROI to extract each
>     individual's mean thickness in the ROI in order to run a
>     correlation with other measures.  Based on this, I assume it would
>     make sense to use smoothed data to identify the ROI and then use
>     unsmoothed data for extracting actual thickness measures (does
>     lh.thickness.fsaverage contain the original thickness or warped
>     thickness values).
>
>     I am unsure which smoothing is the most accurate or preferred.  In
>     using qcache the smoothness of the images do not seem to reach the
>     filter level (based on the earlier email) so I am not sure if
>     there is a freesurfer tool to check the smoothness level or if the
>     qcache smoothness levels make sense for cortical thickness.
>
>     Thanks,
>     Ajay
>
>     On Wed, May 4, 2016 at 5:41 PM, Ajay Kurani
>     <dr.ajay.kur...@gmail.com <mailto:dr.ajay.kur...@gmail.com>> wrote:
>
>         Hi Freesurfer Experts,
>            I am trying to understand the difference between qcache
>         option and mris_fwhm and which is appropriate for a cortical
>         thickness analysis.  I processed my  files with qcache and
>         have lh.thickness.fsaverage.fwhm15.gii (converted) files.  I
>         used an afni tool SurfFWHM to estimate the smoothness of a
>         subject at when looking at the fwhm0 image it iwas 5.5 and for
>         10, 15 and 20mm it was approximately 9.3-9.9 smoothness level.
>
>         I also used mris_fwhm --hemi lh --s fsaverage --smooth-only
>         --i lh.thickness.fsaverage.mgz --fwhm 15 --cortex --o
>         test_15.gii  and when using SurfFWHM on the smae subject the
>         smoothness was estimated at 11.25.
>
>
>         1) I am not sure if the qcache or the mris_fwhm file is more
>         appropriate to use for a cortical thickness analysis.
>
>         2) For qdec if I select the 15mm  option does it assume the
>         smoothness is 15mm when calculating monte carlo corrections? 
>         Would there be a different way to estimate this since my
>         smoothness at 15mm is closer to 10mm?
>
>         Thanks,
>         Ajay
>
>
>
>
>
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-- 
Douglas N. Greve, Ph.D.
MGH-NMR Center
gr...@nmr.mgh.harvard.edu
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Fax: 617-726-7422

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