Hi Bruce,

Exactly I want to be sure that I process my data in the same way, so not
introduce bias with partially use of -bigventricles option.

1) I tried the recon-all process on AD patient with big ventricles and
atrophy with and without the -bigventricles option. I am not pretty sure of
which process is the best in terms of segmentation according the aseg.mgz ?
(I'll send you T1 and aseg.mgz for the two process)
2) Considering cortical atrophy, a lot of gray matter hasn't been taken
account in the cortex segmentation. Is there an automatic way to improve
the cortical segmentation in case of visible atrophy ?

Best regards,
Matthieu

2015-12-03 18:03 GMT+01:00 Bruce Fischl <fis...@nmr.mgh.harvard.edu>:

> Hi Matthie
>
> do you find that it doesn't work well without bigventricles? You just
> want to be sure that you process your data in the same way so there is no
> bias in the results. We have found that most early AD cases work fine
> without needing special flags. It's more for late stage AD or hydrocephalus
> and such.
>
> cheers
> Bruce
>
>
>
> On Thu, 3 Dec 2015, Matthieu
> Vanhoutte wrote:
>
> > Dear FreeSurfer experts,
> >
> > My question is in the title. I'm working on Alzheimer case where most of
> the cases have large
> > ventricles. Is it better in general use to apply -bigventricles option
> on all subjects (for
> > homogeneous calculus or something like that...) or to distinct subtle
> cases of patients with not so
> > big ventricles ?
> >
> > Thanks in advance for helping !
> >
> > Best regards,
> >
> > Matthie
> >
> >
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