Dear Freesurfer experts:
we would appreciate if anyone could advise on the sign choice of Monte Carlo simulation, a question we posted 2 days ago. In examining QDEC results of a contrast of interest, we noticed the results are mainly in cold color (blue), with only two small clusters in warm color (red). When I proceeded with Monte Carlo simulation, if I chose the abs as the sign option in simulation, then no clusters survived. In contrast, some clusters would remain, if I chose the neg sign. Because the uncorrected results were mainly in cold color, it seems reasonable to me to use negative only in the simulation. But I am wondering how the option of abs/neg/pos leads to the disparities and will you please elaborate how the simulation works based on abs/neg/pos. Can I state that my results survived the cluster-level correction if I chose the neg sign in simulation? Thank you very much. Karl
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