Hi Eric the optimal smoothing kernel more or less matches the size of the effect, so it's impossible to say a priori. A bigger kernel is better if there is more widespread subtle thinning
cheers Bruce On Mon, 27 Jul 2015, Erik Lindberg wrote: > Dear freesufers, > I quick question about smoothing of data in cortical thickness analysis. I > have a > comparison that is rather borderline significant. When using smoothing of 10 > mm I > get a limited region in the frontal lobe that is differs between groups. > Changing > to 15 mm I get larger regions - and also some parts of the temporal lobe > differs > in the comparison. > > The 15 mm smoothing provides results that are more consistent with the > hypothesis > - however I do not know if this amount of smoothing overestimate the > difference > between groups? > > Eric > > > _______________________________________________ Freesurfer mailing list Freesurfer@nmr.mgh.harvard.edu https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.org/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail.
