In theory that works, but remember the FS total cranial volume is only 
an estimate based on the talairach transform. It is not counting voxels 
that are inside the skull.

On 10/23/2014 12:30 PM, Mohammed Goryawala wrote:
> Thanks Doug.
>
> I was looking at a paper "ARANGO, C., MCMAHON, R. P., LEFKOWITZ, D. 
> M., PEARLSON, G., KIRKPATRICK, B. & BUCHANAN, R. W. 2008. Patterns of 
> cranial, brain and sulcal CSF volumes in male and female deficit and 
> nondeficit patients with schizophrenia. Psychiatry Research: 
> Neuroimaging, 162, 91-100.", which estimates sulcal CSF volume as
>
>
>         2.4.4. Sulcal CSF (sCSF)
>
> The sCSF was derived by subtracting T
>
> ​otal ​
> B
> ​ rain ​
> V
> ​ olume ​
> and V
> ​ entricular ​
> V
> ​ olume​
> from T
> ​ otal ​
> C
> ​ ranial ​
> V
> olume ​
> .
> ​Can such a strategy be explored using FreeSurfer​ output ?
>
> ​Thanks for your advice
> Mohammed​
>
>
> On Thu, Oct 23, 2014 at 12:16 PM, Douglas N Greve 
> <gr...@nmr.mgh.harvard.edu <mailto:gr...@nmr.mgh.harvard.edu>> wrote:
>
>
>     No, not currently. This is quite a hard problem even if you have a T2.
>     The pulse sequences are usually low enough bandwidth that fat from the
>     scalp and skull marrow shift into the CSF spaces making it
>     impossible to
>     properly segment that area as CSF. If you wanted an approximate value,
>     you could create a binary mask from the aparc+aseg.mgz, dilated it
>     by 3
>     or 4 voxels, then erode it by the same amount, then remove the
>     original
>     mask. The remaining voxels will be something like the sulcal CSF.
>
>     doug
>
>
>     On 10/22/2014 04:50 PM, Mohammed Goryawala wrote:
>     > Hello FreeSurfer Experts,
>     >
>     > Is it possible to estimate the sulcal CSF volume in Freesurfer
>     > processing? If not directly are there any indirect means that
>     can give
>     > me an estimate?
>     >
>     > Thank you
>     >
>     > Mohammed Goryawala, PhD
>     > Department of Radiology
>     > Miller School of Medicine, University of Miami
>     >
>     >
>     >
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>     --
>     Douglas N. Greve, Ph.D.
>     MGH-NMR Center
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-- 
Douglas N. Greve, Ph.D.
MGH-NMR Center
gr...@nmr.mgh.harvard.edu
Phone Number: 617-724-2358
Fax: 617-726-7422

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