Dear freesurfers,
I have a study in which we want to perform group analysis to find the effect of
age on cortical thickness between patients and controls. We have 11 patients
with age group from 45-75 years and the mean of 53. We shall age match our
controls with respect to similar age range and mean.
However our patient scans are from both 1.5T and 3.0T scanner, hence I have few
questions about designing our study.
A) Can we treat certain discrete factors as continuous variables, like gender
(male with value 1 and female with value 2), and scanner (1.5T with value 1 and
3.0T with value 2) to make group analysis qdec-able in case of 3 discrete
factors? I tried to look into mailing archive to figure out the answer, but so
far found confounding answers.
B) If what asked above is possible can you please suggest which design I should
opt for?
Design 1)
Three discrete factors, each with 2 levels:
(i) gender (male and female)
(ii) groups (healthy and patients)
(iii) scanner (1.5T and 3.0T),
Continuous variable:
(i) age
OR
Design 2)
Two discrete factors, each with 2 levels
(i) gender (male and female)
(ii) groups (healthy and patients)
Continuous variables:
(i) age
(ii) scanner (1.5T as 1, and 3.0T as 0)
>From literature we are not expecting any effect of gender and scanner on
>change of cortical thickness with age between groups, however I guess we need
>to control for it right?
Should I implement design 1 with mri_glmfit command line, as it has 3 discrete
factors or design 2 in qdec?
B) We are expecting some change in cortical thickness with age between groups.
Hence we shall be using DODS model to perform the analysis. In this case I
should demean my ages right (subtract grand mean of age from combined healthy
and patient groups and subtract from every individual age)?
Thanks,
Sneha
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