Hi Florian - Tracula has certain expectations for what aparc+aseg labels 
each tract goes through or next to, and it'll skip areas that don't match 
those expectations. If the voxels in the lesions get labeled in the 
aparc+aseg, e.g. as white-matter hypointensities instead of white matter, 
you can switch those voxels to the white matter label, and then tracula 
will treat them like the rest of white matter. I should probably add an 
option for trac-all to be able to do that in the next version.

For now, you can change those voxels in mri/aparc+aseg.mgz (first keep a 
copy of the original file under another name for all other intents and 
purposes!) and then rerun trac-all. You can skip the trac-all steps before 
-masks, that's the step where it grabs the aparc+aseg to use in subsequent 
steps.

Hope this helps,
a.y

On Wed, 16 Apr 2014, Florian Borsodi wrote:

> Dear Freesurfer TRACULA Experts,
>
> We are trying to run TRACULA on patients with lesions and found out, that 
> TRACULA had problems tracking streamlines trough the lesions, which is 
> understandable. The problem is, if TRACULA gets lost in the lesions, the 
> whole streamline is not considered, even if the streamline until the lesion 
> might be correct!
>
> Is there any possibility to hand TRACULA lesionmasks, so that the regions 
> with lesions are ignored? If not, is there a possibility to maintain the lost 
> streamlines, or at least parts of it?
>
> Thank you in advance for your help.
>
> With kind regards,
>
> Florian Borsodi, Lukas Pirpamer
> Department of Neurology
> Medical Universtiy of Graz
>
>
>
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