Hi Helen, I would follow these steps
http://surfer.nmr.mgh.harvard.edu/fswiki/Xhemi
this describes the interhemispheric analysis assuming that you want to 
study asymmetry. This is not quite your application, but I think it will 
work well for it. In general, you don't want to simply left-right 
reverse the pixel data because the atlases used in processing implicitly 
incorporate any left-right asymmetry that existed in the training data.
doug

On 11/20/2012 12:36 PM, Chen, Xiaoyan wrote:
> Dear Freesurfer experts,
>
>                                     I have a general question regarding data 
> analysis. Our group has collected data from patients with OA, some of them 
> received treatment on their left leg, some of them on their right leg. We 
> would like to flip the brain for the people that received treatment on their 
> left leg to match the right leg group. Next, we would like perform group 
> analysis on them. My question is, when should we flip the brain for the left 
> leg group patients? Should we flip the raw images before we do any 
> preprocessing at the individual level? Or should we flip the first level 
> contrast images when we get some results for each of these subjects? I tried 
> to flip the contrast images, but it seems to give me a lot of error at the 
> second level group analysis level. It says that the flipped contrast image 
> does not match the unflipped contrast image in orientation. Thank you very 
> much.
>
>
> Helen
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>

-- 
Douglas N. Greve, Ph.D.
MGH-NMR Center
gr...@nmr.mgh.harvard.edu
Phone Number: 617-724-2358
Fax: 617-726-7422

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