Hi Bruce,

Thank's for the reply! I'm not concerned about hippocampal volume for 
now, mostly needing cortical thickness for my project! Yes, I am using 
v5.1. So in case of cortical thickness I shouldn't worry too much about 
Talairach registration? could you please tell me what are the main 
things I should check and pay attention to for cortical thickness? I'm 
following the troubleshooting page 
(http://surfer.nmr.mgh.harvard.edu/fswiki/RecommendedReconstruction) and 
I see some discrepancies in the pial/WM surfaces but again I am not sure 
how much I should correct!

Thanks again,
-Mojdeh

On 07/20/2012 04:15 PM, Bruce Fischl wrote:
> Hi Mojdeh
>
> it won't affect any individual thickness measures, *but* will affect 
> the estimated total intracranial volume (eTIV). We don't typically use 
> eTIV for thickness correction, but do for things like hippocampal 
> volume. Are you using version 5.1? If so, that's the problem. Nick has 
> a fix for this that he can direct you about, or you can wait for 5.2 
> and rerun the Talairach registration then.
>
> cheers
> Bruce
>
>
> On Fri, 20 Jul 2012, Mojdeh Zamyadi wrote:
>
>> Hi all,
>>
>> Sorry for re-posting this but it seems it didn't get through!
>>
>> I've just started to do cortical thickness analysis on some subjects and
>> I'm noticing some miss-registrations, more specifically the Talairach
>> image is smaller than the target image no matter what subject I look at!
>> I just wanted to make sure if this is something normal and to what
>> extend it's going to effect the individual cortical thickness
>> calculations. I guess I'm not sure how the Talairach transformation is
>> used in further steps of the cortical thickness calculation.
>>
>> I tried to attach example coronal, sagittal and horizontal slices of one
>> of my subjects but apparently it was too big for the mailing list. Pleas
>> let me know if there is a way to attach images here.
>>
>> I greatly appreciate your advice.
>>
>> Thanks,
>> Mojdeh Zamyadi, MSc
>> Clinical Research Project Assistant
>> The Hospital for Sick Children
>> 555 University Avenue
>> Toronto, ON, M5G 1X8
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