Hi Cat,

you can run 5.1 base and longitudinal on top of 5.0 cross sectional runs. Since 
you have not edited anything yet, I would however recommend to re-run the cross 
scectional runs with 5.1

For edits, please look at the wiki page 
http://surfer.nmr.mgh.harvard.edu/fswiki/LongitudinalEdits
also there are examples in the longitudinal tutorial.

Basically : edit the cross, then edit the base, then there should be no need to 
edit the long.
In some cases you may get away with only editing the base.

Best, Martin

  ----- Original Message ----- 
  From: Cat Chong 
  To: freesurfer@nmr.mgh.harvard.edu 
  Sent: Thursday, April 19, 2012 12:21 AM
  Subject: [Freesurfer] longitudinal analysis 5.0 or 5.1?



  Dear Freesurfers:

  We have a large group of subjects (for which we have two time-points) that 
were run  through the recon-all stream using 5.0.  We have done no manual 
editing yet.

  We would like to do a longitudinal analysis of these subjects using 5.1 by 
comparing both time-points for each subject.  Is that a possibility using 5.1? 

  Also, at what point should I correct for topographical defects, or make edits 
to the white matter or brain mask volume?
  Should I edit both time-points separately first and then initiate the 
longitudinal analysis? If so, could I do the manual editing using 5.1?


  thank you very much for your help,
  cheers,
  cat


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