Hi Bruce,
Can you elaborate briefly on the 6-connected bit?  e.g., if one places a
CP manually in a voxel, and that CP is not face-connected on all sides
to either other manually-placed CPs, or CPs determined automatically by
FS, then it doesn't get counted as a CP after all?

Is there any volume that allows one to see the automatically generated
CPs?

Something definitely seems wonky about the inclusion of the manually-
specified CPs as part of the aseg normalization (mri_ca_normalize),
because the resulting norm.mgz (and thus eventually brain.mgz) ends up
differing appreciably in locations distant from the manually placed CPs.
In contrast, if you skip the re-creation of the norm.mgz by using the -
nocanorm flag, the resulting brain.mgz is much more reasonably behaved,
with its largest differences in the vicinity of the CPs.

thanks,
-MH

On Fri, 2012-01-27 at 14:58 -0500, Bruce Fischl wrote:
> Hi Mike
> 
> it's a bit hard to state the region of effect for the control points. 
> Essentially we go through and label voxels as control points or not based 
> on their intensity, intensity gradient and connectivity (that is, the must 
> be 6-connected to other control points) then build a Voronoi diagram and 
> each control point sets the scaling for its Voronoi triangle. Thus if you 
> have a control point surrounded by others its region of effect is small, 
> but one control point all by itself can have a large region of effect.
> 
> Also, 5.1  applies the manually specified control points to the aseg 
> normalization (norm.mgz), whereas older versions didn't. Not everyone is 
> happy with this, so I think there is a backwards compatibility flag. Nick 
> would know.
> 
> Bruce
> 
> On Fri, 27 Jan 2012, Sabin Khadka wrote:
> 
> > Hi Michael,I had the same problem too. It might be because of the type of 
> > scanner you are using. I added -washu_mprage flag, it pretty
> > much helped me (I did not had to add a lot of controls points and so on so 
> > forth. You can go through the link below.
> > 
> > https://mail.nmr.mgh.harvard.edu/pipermail//freesurfer/2009-August/011695.html
> >  
> > 
> > Hope it helps.
> > 
> > -SK
> > 
> > On Fri, Jan 27, 2012 at 12:06 PM, Michael Harms <mha...@conte.wustl.edu> 
> > wrote:
> >
> >       Hi guys,
> >
> >       We are currently trying to fix some errors in the white/pial surfaces
> >       where there are thin white matter strands by using control points, and
> >       are noticing a couple things:
> >
> >       1) The resulting WM surface in the area of the CPs can end up too far
> >       into the GM instead.  Given that, is there any practical guidance for
> >       how to think about the surrounding spatial extent that is impacted by 
> > a
> >       given CP?  i.e., How do CP's actually get used within mri_normalize in
> >       an algorithmic sense?
> >
> >       2) The surfaces are being impacted in places distant from the CPs.
> >       e.g., CP's placed in the left anterior temporal lobe are resulting in
> >       surface changes in the right anterior temporal lobe.  And when I
> >       difference the original norm.mgz vs. the one obtained after using 
> > CP's,
> >       I'm seeing an odd pattern of intensity differences which is clearly 
> > not
> >       limited to just the area of the CP's (which would be my expectation).
> >
> >       This is version 5.1.
> >
> >       thanks,
> >       -MH
> > 
> >
> >       --
> >       Michael Harms, Ph.D.
> >       --------------------------------------------------------------------
> >       Conte Center for the Neuroscience of Mental Disorders
> >       Washington University School of Medicine
> >       Department of Psychiatry, Box 8134
> >       Renard Hospital, Room 6604           Tel: 314-747-6173
> >       660 South Euclid Ave.                Fax: 314-747-2182
> >       St. Louis, MO 63110                  Email: mha...@wustl.edu
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