Thank you Michael,

I was wondering about a nuisance specific to area analysis. I
understand using ICV or brain volume in volumetric analysis, but for
area analysis something like "overall pial area" seems more logical to
me. That is why I am curious if there is any literature about area
(surface) analysis in particular. Am I at the right track at all?
Best wishes,
Tanja.

On Wed, Nov 2, 2011 at 2:15 PM, Michael Harms <mha...@conte.wustl.edu> wrote:
>
> Typically one uses either a measure of "brain volume" or an estimate of
> intracranial volume -- the choice depends on whether or not you want to
> control for whole brain atrophy when making your interpretations, in
> which case you would use "brain volume" rather than ICV.  There have
> been numerous posts to the list on this issue, so try searching the
> archives.
>
> As for articles, you could start with the ones below.
>
> cheers,
> -MH
>
>
> 1: Mathalon DH, Sullivan EV, Rawles JM, Pfefferbaum A. Correction for
> head size
> in brain-imaging measurements. Psychiatry Res. 1993 Jun;50(2):121-39. Erratum 
> in:
> Psychiatry Res 1994 Sep;55(3):179. PubMed PMID: 8378488.
>
>
> 2: Arndt S, Cohen G, Alliger RJ, Swayze VW 2nd, Andreasen NC. Problems with 
> ratio
> and proportion measures of imaged cerebral structures. Psychiatry Res. 1991
> May;40(1):79-89. PubMed PMID: 1946842.
>
>
> 3: O'Brien LM, Ziegler DA, Deutsch CK, Kennedy DN, Goldstein JM, Seidman LJ,
> Hodge S, Makris N, Caviness V, Frazier JA, Herbert MR. Adjustment for whole 
> brain
> and cranial size in volumetric brain studies: a review of common adjustment
> factors and statistical methods. Harv Rev Psychiatry. 2006 
> May-Jun;14(3):141-51.
> Review. PubMed PMID: 16787886.
>
>
> 4: O'Brien LM, Ziegler DA, Deutsch CK, Frazier JA, Herbert MR, Locascio JJ.
> Statistical adjustments for brain size in volumetric neuroimaging studies: 
> some
> practical implications in methods. Psychiatry Res. 2011 Aug 30;193(2):113-22.
> PubMed PMID: 21684724.
>
>
> 5: Sanfilipo MP, Benedict RH, Zivadinov R, Bakshi R. Correction for 
> intracranial
> volume in analysis of whole brain atrophy in multiple sclerosis: the 
> proportion
> vs. residual method. Neuroimage. 2004 Aug;22(4):1732-43. PubMed PMID: 
> 15275929.
>
>
> On Wed, 2011-11-02 at 12:26 +0100, Tetiana Dadakova wrote:
>> Dear FreeSurfer experts,
>>
>> I have a question regarding pial area analysis.
>>
>> What is commonly used as a nuisance variable to correct for brain size
>> difference between groups (e.g men vs women)? Can you suggest any
>> article where this is discussed or has been done?
>>
>> Thank you,
>> Tanja.
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