Hi Mario,

I'm not sure what an N4 correction is, but the Freesurfer team helped me to
solve the problem. Here are their instructions:

Sometimes when the skullstrip is wrong, it affects the surfaces even if the
wm parcellation is correct. I ran -skullstrip with the watershed parameter
of 30, and then reran the subject with -autorecon2 -autorecon3. You can find
info how how to run watershed here:
http://surfer.nmr.mgh.harvard.edu/fswiki/FsTutorial/SkullStripFix

<http://surfer.nmr.mgh.harvard.edu/fswiki/FsTutorial/SkullStripFix>I hope
this helps! I can send over our full conversation if this doesn't give you
the information you need.

Allie



On Fri, May 13, 2011 at 4:26 PM, Mario Ortega <mario.ort...@gmail.com>wrote:

> HI Allie,
> I am having this exact issue, and I was able to fix only a few of them, Did
> the Freesurfer team ever give you a reliable fix? I used an N4 correction
> before the entire FS process.
> -Mario
>
>
> On Wed, Apr 20, 2011 at 8:32 AM, Allie Rosen <rosen.al...@gmail.com>wrote:
>
>> Hi,
>>
>> Do you want me to email you in a few days about this?
>>
>> Allie
>>
>>
>>
>>
>> On Tue, Apr 19, 2011 at 10:25 AM, Khoa Nguyen 
>> <k...@nmr.mgh.harvard.edu>wrote:
>>
>>> Got it. I'll look at it and get back to you.
>>>
>>>
>>> On Tue, 19 Apr 2011, Allie Rosen wrote:
>>>
>>>  Hi,
>>>>
>>>> http://dl.dropbox.com/u/14127241/C42.tar.gz
>>>>
>>>> Here is the link to the subject. I hope this works!!
>>>>
>>>> Allie
>>>>
>>>>
>>>>
>>>> On Tue, Apr 19, 2011 at 9:38 AM, Khoa Nguyen <k...@nmr.mgh.harvard.edu
>>>> >wrote:
>>>>
>>>>  Another way you can try is upload it to your google doc account and
>>>>> send me
>>>>> the link. Someone did that before.
>>>>>
>>>>>
>>>>> On Tue, 19 Apr 2011, Allie Rosen wrote:
>>>>>
>>>>>  Hi,
>>>>>
>>>>>>
>>>>>> No, I'm not from the centre. I'm working on putting the files in
>>>>>> Dropbox
>>>>>> and
>>>>>> sending you a link to them, because apparently I don't have ftp
>>>>>> access.
>>>>>>
>>>>>> Allie
>>>>>>
>>>>>>
>>>>>>
>>>>>> On Tue, Apr 19, 2011 at 8:37 AM, Khoa Nguyen <
>>>>>> k...@nmr.mgh.harvard.edu
>>>>>>
>>>>>>> wrote:
>>>>>>>
>>>>>>
>>>>>>  Are you from the center? If so you can just cd into /space/outgoing
>>>>>> and
>>>>>>
>>>>>>> copy your file there. If not, you can follow the instructions in the
>>>>>>> box
>>>>>>> at
>>>>>>> the top using a terminal.
>>>>>>>
>>>>>>>
>>>>>>> On Tue, 19 Apr 2011, Allie Rosen wrote:
>>>>>>>
>>>>>>>  Hi,
>>>>>>>
>>>>>>>
>>>>>>>> I'm really sorry, but I don't understand those instructions. Do I
>>>>>>>> login
>>>>>>>> to
>>>>>>>> the freesurfer website? Or do I login through a terminal somehow? Do
>>>>>>>> I
>>>>>>>> type
>>>>>>>> the stuff in the boxes into the terminal?
>>>>>>>>
>>>>>>>> Thanks,
>>>>>>>> Allie
>>>>>>>>
>>>>>>>>
>>>>>>>> On Tue, Apr 19, 2011 at 8:18 AM, Khoa Nguyen <
>>>>>>>> k...@nmr.mgh.harvard.edu
>>>>>>>>
>>>>>>>>  wrote:
>>>>>>>>>
>>>>>>>>>
>>>>>>>>  Hi Allie,
>>>>>>>>
>>>>>>>>
>>>>>>>>> You can compress the subject dir and upload it following the
>>>>>>>>> instructions
>>>>>>>>> here
>>>>>>>>> http://surfer.nmr.mgh.harvard.edu/fswiki/FtpFileExchange
>>>>>>>>>
>>>>>>>>>
>>>>>>>>>
>>>>>>>>> On Tue, 19 Apr 2011, Allie Rosen wrote:
>>>>>>>>>
>>>>>>>>>  Hi Khoa,
>>>>>>>>>
>>>>>>>>>
>>>>>>>>>  How do I upload subjects?
>>>>>>>>>>
>>>>>>>>>> Thanks,
>>>>>>>>>> Allie
>>>>>>>>>>
>>>>>>>>>>
>>>>>>>>>>
>>>>>>>>>> On Tue, Apr 19, 2011 at 8:06 AM, Khoa Nguyen <
>>>>>>>>>> k...@nmr.mgh.harvard.edu
>>>>>>>>>>
>>>>>>>>>>  wrote:
>>>>>>>>>>
>>>>>>>>>>>
>>>>>>>>>>>
>>>>>>>>>>>   Hi Allie,
>>>>>>>>>>
>>>>>>>>>>
>>>>>>>>>>  Can you upload the subject? I'll take a look and see if I can
>>>>>>>>>>> figure
>>>>>>>>>>> out
>>>>>>>>>>> what's wrong.
>>>>>>>>>>>
>>>>>>>>>>> -Khoa
>>>>>>>>>>>
>>>>>>>>>>>
>>>>>>>>>>> On Tue, 19 Apr 2011, Allie Rosen wrote:
>>>>>>>>>>>
>>>>>>>>>>>  Hi,
>>>>>>>>>>>
>>>>>>>>>>>
>>>>>>>>>>>  This (recon-all after wm.mgz and brainmask.mgz edits) didn't
>>>>>>>>>>> work.
>>>>>>>>>>>
>>>>>>>>>>>> The
>>>>>>>>>>>> part
>>>>>>>>>>>> that wasn't included in the pial or white matter surfaces is
>>>>>>>>>>>> still
>>>>>>>>>>>> not
>>>>>>>>>>>> included. The intensities in the white matter regions are no
>>>>>>>>>>>> different
>>>>>>>>>>>> than
>>>>>>>>>>>> in white matter regions that were included in the white matter.
>>>>>>>>>>>> Any
>>>>>>>>>>>> other
>>>>>>>>>>>> suggestions?
>>>>>>>>>>>>
>>>>>>>>>>>> Thanks,
>>>>>>>>>>>> Allie
>>>>>>>>>>>>
>>>>>>>>>>>>
>>>>>>>>>>>>
>>>>>>>>>>>> On Mon, Apr 18, 2011 at 7:53 PM, Allie Rosen <
>>>>>>>>>>>> rosen.al...@gmail.com
>>>>>>>>>>>>
>>>>>>>>>>>>>
>>>>>>>>>>>>>  wrote:
>>>>>>>>>>>>
>>>>>>>>>>>>  Hi Bruce,
>>>>>>>>>>>>
>>>>>>>>>>>>
>>>>>>>>>>>>  I am running recon-all tonight using wm voxels that I manually
>>>>>>>>>>>>
>>>>>>>>>>>>> added
>>>>>>>>>>>>> (I
>>>>>>>>>>>>> also edited brainmask.mgz to add missing grey matter). To me it
>>>>>>>>>>>>> doesn't
>>>>>>>>>>>>> really look like a case of the white matter not having a high
>>>>>>>>>>>>> enough
>>>>>>>>>>>>> intensity. It simply looks like the whole lobe was ignored,
>>>>>>>>>>>>> regardless
>>>>>>>>>>>>> of
>>>>>>>>>>>>> intensity. But I'll check tomorrow to see if the intensity is
>>>>>>>>>>>>> low.
>>>>>>>>>>>>>
>>>>>>>>>>>>> Thanks,
>>>>>>>>>>>>> Allie
>>>>>>>>>>>>>
>>>>>>>>>>>>>
>>>>>>>>>>>>> On Mon, Apr 18, 2011 at 7:38 PM, Bruce Fischl <
>>>>>>>>>>>>> fis...@nmr.mgh.harvard.edu>wrote:
>>>>>>>>>>>>>
>>>>>>>>>>>>>  What is the intensity of the white matter in the regions you
>>>>>>>>>>>>> drew
>>>>>>>>>>>>> in?
>>>>>>>>>>>>> A
>>>>>>>>>>>>>
>>>>>>>>>>>>>  couple of control points might help if it is less than 110
>>>>>>>>>>>>>
>>>>>>>>>>>>>
>>>>>>>>>>>>>>
>>>>>>>>>>>>>>
>>>>>>>>>>>>>> On Apr 18, 2011, at 12:36 PM, Allie Rosen <
>>>>>>>>>>>>>> rosen.al...@gmail.com>
>>>>>>>>>>>>>> wrote:
>>>>>>>>>>>>>>
>>>>>>>>>>>>>> Hi Sita,
>>>>>>>>>>>>>>
>>>>>>>>>>>>>> Thanks for all the responses! I've actually had the same
>>>>>>>>>>>>>> problem
>>>>>>>>>>>>>> for
>>>>>>>>>>>>>> multiple subjects. I'm using version 5.0.0. I'll try fixing
>>>>>>>>>>>>>> the
>>>>>>>>>>>>>> cerebellum
>>>>>>>>>>>>>> as well. I've attached pictures of where I am adding wm
>>>>>>>>>>>>>> voxels.
>>>>>>>>>>>>>> They
>>>>>>>>>>>>>> aren't
>>>>>>>>>>>>>> really in the same places as in the online tutorials. Could
>>>>>>>>>>>>>> you
>>>>>>>>>>>>>> take
>>>>>>>>>>>>>> a
>>>>>>>>>>>>>> quick
>>>>>>>>>>>>>> look to see if they're in the right place?
>>>>>>>>>>>>>>
>>>>>>>>>>>>>> Thanks,
>>>>>>>>>>>>>> Allie
>>>>>>>>>>>>>>
>>>>>>>>>>>>>>
>>>>>>>>>>>>>>
>>>>>>>>>>>>>>
>>>>>>>>>>>>>> On Mon, Apr 18, 2011 at 12:31 PM, Sita Kakunoori <<
>>>>>>>>>>>>>> s...@nmr.mgh.harvard.edu>
>>>>>>>>>>>>>> s...@nmr.mgh.harvard.edu> wrote:
>>>>>>>>>>>>>>
>>>>>>>>>>>>>>
>>>>>>>>>>>>>>  Hi Allie,
>>>>>>>>>>>>>>
>>>>>>>>>>>>>>
>>>>>>>>>>>>>>  pial surface which looks like this can only be corrected by
>>>>>>>>>>>>>>> correcting
>>>>>>>>>>>>>>> the wm.mgz. Also I would suggest to try and fix the
>>>>>>>>>>>>>>> cerebellum
>>>>>>>>>>>>>>> and
>>>>>>>>>>>>>>> see
>>>>>>>>>>>>>>> if it
>>>>>>>>>>>>>>> corrects the surfaces as well. Since part of the cerebellum
>>>>>>>>>>>>>>> is
>>>>>>>>>>>>>>> stripped
>>>>>>>>>>>>>>> off,
>>>>>>>>>>>>>>> it's probably affecting the segmentation as well but I could
>>>>>>>>>>>>>>> be
>>>>>>>>>>>>>>> wrong.
>>>>>>>>>>>>>>> what
>>>>>>>>>>>>>>> version of freesurfer are you using.
>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>> Sita.
>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>> On Mon, 18 Apr 2011, Allie Rosen wrote:
>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>  Hi Sita,
>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>  Can I still add voxels to wm.mgz even though the points
>>>>>>>>>>>>>>> would be
>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>  outside
>>>>>>>>>>>>>>>> even the pial boundary?
>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>> Thanks
>>>>>>>>>>>>>>>> Allie
>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>> On Mon, Apr 18, 2011 at 12:18 PM, Sita Kakunoori
>>>>>>>>>>>>>>>> < <s...@nmr.mgh.harvard.edu>s...@nmr.mgh.harvard.edu>wrote:
>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>  Hi Allie,
>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>  This probably needs white matter edits but it's hard to
>>>>>>>>>>>>>>>> tell
>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>> from
>>>>>>>>>>>>>>>>> one
>>>>>>>>>>>>>>>>> slice. Please refer to our white matter edits wiki and
>>>>>>>>>>>>>>>>> toplogical
>>>>>>>>>>>>>>>>> defects
>>>>>>>>>>>>>>>>> wiki and see if it helps in fixing the errors in your
>>>>>>>>>>>>>>>>> datasets.
>>>>>>>>>>>>>>>>> Also
>>>>>>>>>>>>>>>>> it
>>>>>>>>>>>>>>>>> looks like part of the Cerebellum is stripped off. You
>>>>>>>>>>>>>>>>> might
>>>>>>>>>>>>>>>>> want
>>>>>>>>>>>>>>>>> to
>>>>>>>>>>>>>>>>> correct
>>>>>>>>>>>>>>>>> that as well.
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>> <
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>> https://surfer.nmr.mgh.harvard.edu/fswiki/FsTutorial/WhiteMatterEdits
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>> https://surfer.nmr.mgh.harvard.edu/fswiki/FsTutorial/WhiteMatterEdits
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>> <
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>> https://surfer.nmr.mgh.harvard.edu/fswiki/FsTutorial/TopologicalDefect
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>> https://surfer.nmr.mgh.harvard.edu/fswiki/FsTutorial/TopologicalDefect
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>> Sita.
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>> On Mon, 18 Apr 2011, Allie Rosen wrote:
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>  Hi,
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>  Once processed, several of my subjects have had errors
>>>>>>>>>>>>>>>>> around
>>>>>>>>>>>>>>>>> the
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>  occipital
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>> lobe. Attached is an example. I've already tried editing
>>>>>>>>>>>>>>>>>> brainmask.mgz
>>>>>>>>>>>>>>>>>> and
>>>>>>>>>>>>>>>>>> running recon-all, but as you can see, this didn't change
>>>>>>>>>>>>>>>>>> the
>>>>>>>>>>>>>>>>>> pial
>>>>>>>>>>>>>>>>>> or
>>>>>>>>>>>>>>>>>> wm
>>>>>>>>>>>>>>>>>> borders. What can I do to fix this?
>>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>> Thank you,
>>>>>>>>>>>>>>>>>> Allie Rosen, MSc Candidate
>>>>>>>>>>>>>>>>>> Graduate Student, Department of Neurosurgery
>>>>>>>>>>>>>>>>>> Toronto Western Hospital 14-327
>>>>>>>>>>>>>>>>>> 399 Bathurst St.
>>>>>>>>>>>>>>>>>> University of Toronto
>>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>>  The information in this e-mail is intended only for the
>>>>>>>>>>>>>>>>>> person
>>>>>>>>>>>>>>>>>> to
>>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>>  whom
>>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>>  it
>>>>>>>>>>>>>>>>> is
>>>>>>>>>>>>>>>>> addressed. If you believe this e-mail was sent to you in
>>>>>>>>>>>>>>>>> error
>>>>>>>>>>>>>>>>> and
>>>>>>>>>>>>>>>>> the
>>>>>>>>>>>>>>>>> e-mail
>>>>>>>>>>>>>>>>> contains patient information, please contact the Partners
>>>>>>>>>>>>>>>>> Compliance
>>>>>>>>>>>>>>>>> HelpLine at
>>>>>>>>>>>>>>>>>  <http://www.partners.org/complianceline>
>>>>>>>>>>>>>>>>> http://www.partners.org/complianceline . If the e-mail was
>>>>>>>>>>>>>>>>> sent
>>>>>>>>>>>>>>>>> to
>>>>>>>>>>>>>>>>> you
>>>>>>>>>>>>>>>>> in
>>>>>>>>>>>>>>>>> error
>>>>>>>>>>>>>>>>> but does not contain patient information, please contact
>>>>>>>>>>>>>>>>> the
>>>>>>>>>>>>>>>>> sender
>>>>>>>>>>>>>>>>> and
>>>>>>>>>>>>>>>>> properly
>>>>>>>>>>>>>>>>> dispose of the e-mail.
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>  <2.png>
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>  <3.png>
>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>
>>>>>>>>>>>>>> _______________________________________________
>>>>>>>>>>>>>> Freesurfer mailing list
>>>>>>>>>>>>>> Freesurfer@nmr.mgh.harvard.edu
>>>>>>>>>>>>>> https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
>>>>>>>>>>>>>>
>>>>>>>>>>>>>>
>>>>>>>>>>>>>>
>>>>>>>>>>>>>>
>>>>>>>>>>>>>>
>>>>>>>>>>>>>>
>>>>>>>>>>>>>>
>>>>>>>>>>>>>
>>>>>>>>>>>>
>>>>>>>>>>
>>>>>>>>
>>>>>>
>>>>
>>
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