On Sat, Aug 1, 2020 at 11:25 AM Jason Resch <[email protected]> wrote:

> On Fri, Jul 31, 2020 at 8:13 PM Bruce Kellett <[email protected]>
> wrote:
>
>> On Sat, Aug 1, 2020 at 10:49 AM Jason Resch <[email protected]> wrote:
>>
>>> On Fri, Jul 31, 2020 at 7:37 PM PGC <[email protected]> wrote:
>>>
>>>> On Saturday, August 1, 2020 at 2:26:40 AM UTC+2, Jason wrote:
>>>>>
>>>>> On Fri, Jul 31, 2020 at 7:20 PM PGC <[email protected]> wrote:
>>>>>
>>>>>> On Saturday, August 1, 2020 at 1:12:49 AM UTC+2, Jason wrote:
>>>>>>>
>>>>>>> There have been 65 studies on HCQ. Of all the tests that looked at
>>>>>>> giving it early in the disease, or prophylactically, they showed HCQ was
>>>>>>> beneficial. This site summarizes them all: https://c19study.com/
>>>>>>>
>>>>>>> The only studies that have shown HCQ to be ineffective are those
>>>>>>> where it is given late in the disease progression (when the disease 
>>>>>>> shifts
>>>>>>> from the viral replication phase to an immune system dysregulation
>>>>>>> phase
>>>>>>> <https://www.evms.edu/media/evms_public/departments/internal_medicine/EVMS_Critical_Care_COVID-19_Protocol.pdf>
>>>>>>> (see page 2)). Even then, 61% of studies have shown some effectiveness 
>>>>>>> even
>>>>>>> when it is given late.
>>>>>>>
>>>>>>> Given the well-established safety
>>>>>>> <https://www.cdc.gov/malaria/resources/pdf/fsp/drugs/Hydroxychloroquine.pdf>
>>>>>>> record of HCQ, this is the dilemma we face:
>>>>>>>
>>>>>>> HCQ works HCQ doesn't work
>>>>>>> HCQ widely dispensed 10,000s of thousands of lives saved $20 wasted
>>>>>>> per patient
>>>>>>> HCQ use restricted 10,000s of thousands of needless deaths $0
>>>>>>> wasted per patient
>>>>>>>
>>>>>>> Even in the face of impartial information on its effectiveness, the
>>>>>>> decision is clear.
>>>>>>>
>>>>>>
>>>>>>
>>>>>> https://www.who.int/news-room/detail/04-07-2020-who-discontinues-hydroxychloroquine-and-lopinavir-ritonavir-treatment-arms-for-covid-19
>>>>>>
>>>>>> Why not find out from the WHO or the steering committee itself? Just
>>>>>> be prepared to wait as I believe they are somewhat busy.
>>>>>>
>>>>>> But contact them
>>>>>>
>>>>>
>>>>> Find out what from the WHO?
>>>>>
>>>>
>>>> Why they discontinued the treatment arm and why you think they should
>>>> re-establish it (again btw) to save thousands of lives, with your table and
>>>> the website. PGC
>>>>
>>>>>
>>>>
>>> It's purely a decision theory problem. They WHO is not infallible (and
>>> have demonstrated that recently), the science on HCQs effectiveness is
>>> mixed, the science on its safety is clear.
>>>
>>> Given that there is a clearly optimal decision with a higher expected
>>> value.
>>>
>>
>>
>> Your table above presents a false dichotomy.
>>
>
> It either works or doesn't. That's two options. Unless you can point out a
> third one that I missed.
>

It is a false dichotomy, because it misses the nuance that it might be
useful with early administration, but is not a cure, and does not save
lives.

>
>
>> There is no evidence that use of HCQ is effective as a cure for COVID-19.
>>
>
> "No evidence" is a rather poor way to describe "*100% of scientific
> studies that have investigated it's early administration*" (see:
> https://c19study.com/ )
>

Having lots of studies does not prove that something works. They may not
present any evidence at all for efficacy as a cure.

It was only ever suggested that it might act prophylactically, or in relief
>> of some early stage symptoms. Decision theory is only useful if you don't
>> misrepresent the facts....
>>
>
> What is misrepresented by the table? Either it works or it doesn't.
>

False dichotomy, as explained.

Bruce

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