On Fri, Jul 31, 2020 at 8:13 PM Bruce Kellett <[email protected]> wrote:

> On Sat, Aug 1, 2020 at 10:49 AM Jason Resch <[email protected]> wrote:
>
>> On Fri, Jul 31, 2020 at 7:37 PM PGC <[email protected]> wrote:
>>
>>> On Saturday, August 1, 2020 at 2:26:40 AM UTC+2, Jason wrote:
>>>>
>>>> On Fri, Jul 31, 2020 at 7:20 PM PGC <[email protected]> wrote:
>>>>
>>>>> On Saturday, August 1, 2020 at 1:12:49 AM UTC+2, Jason wrote:
>>>>>>
>>>>>> There have been 65 studies on HCQ. Of all the tests that looked at
>>>>>> giving it early in the disease, or prophylactically, they showed HCQ was
>>>>>> beneficial. This site summarizes them all: https://c19study.com/
>>>>>>
>>>>>> The only studies that have shown HCQ to be ineffective are those
>>>>>> where it is given late in the disease progression (when the disease 
>>>>>> shifts
>>>>>> from the viral replication phase to an immune system dysregulation
>>>>>> phase
>>>>>> <https://www.evms.edu/media/evms_public/departments/internal_medicine/EVMS_Critical_Care_COVID-19_Protocol.pdf>
>>>>>> (see page 2)). Even then, 61% of studies have shown some effectiveness 
>>>>>> even
>>>>>> when it is given late.
>>>>>>
>>>>>> Given the well-established safety
>>>>>> <https://www.cdc.gov/malaria/resources/pdf/fsp/drugs/Hydroxychloroquine.pdf>
>>>>>> record of HCQ, this is the dilemma we face:
>>>>>>
>>>>>> HCQ works HCQ doesn't work
>>>>>> HCQ widely dispensed 10,000s of thousands of lives saved $20 wasted
>>>>>> per patient
>>>>>> HCQ use restricted 10,000s of thousands of needless deaths $0 wasted
>>>>>> per patient
>>>>>>
>>>>>> Even in the face of impartial information on its effectiveness, the
>>>>>> decision is clear.
>>>>>>
>>>>>
>>>>>
>>>>> https://www.who.int/news-room/detail/04-07-2020-who-discontinues-hydroxychloroquine-and-lopinavir-ritonavir-treatment-arms-for-covid-19
>>>>>
>>>>> Why not find out from the WHO or the steering committee itself? Just
>>>>> be prepared to wait as I believe they are somewhat busy.
>>>>>
>>>>> But contact them
>>>>>
>>>>
>>>> Find out what from the WHO?
>>>>
>>>
>>> Why they discontinued the treatment arm and why you think they should
>>> re-establish it (again btw) to save thousands of lives, with your table and
>>> the website. PGC
>>>
>>>>
>>>
>> It's purely a decision theory problem. They WHO is not infallible (and
>> have demonstrated that recently), the science on HCQs effectiveness is
>> mixed, the science on its safety is clear.
>>
>> Given that there is a clearly optimal decision with a higher expected
>> value.
>>
>
>
> Your table above presents a false dichotomy.
>

It either works or doesn't. That's two options. Unless you can point out a
third one that I missed.


> There is no evidence that use of HCQ is effective as a cure for COVID-19.
>

"No evidence" is a rather poor way to describe "*100% of scientific studies
that have investigated it's early administration*" (see:
https://c19study.com/ )


> It was only ever suggested that it might act prophylactically, or in
> relief of some early stage symptoms. Decision theory is only useful if you
> don't misrepresent the facts....
>

What is misrepresented by the table? Either it works or it doesn't.

Jason


>
> Bruce
>
>>
>> The very link you provided says they only cancelled only the late stage
>> testing. They are continuing early and prophylactic use tests.
>>
>> "This decision applies only to the conduct of the Solidarity trial in
>> hospitalized patients and does not affect the possible evaluation in other
>> studies of hydroxychloroquine or lopinavir/ritonavir in non-hospitalized
>> patients or as pre- or post-exposure prophylaxis for COVID-19."
>>
>>
>> Jason
>>
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