*Dear CCP4 Community,*
*
We are excited to announce a unique postdoctoral opportunity for a STEM
professional to work on cutting-edge AI applications in structural
biology through the ARISE2 MSCA-funded fellowship program.
Our project, led by the Elofsson and Velankar teams, aims to address
computational challenges in predicting large biomacromolecular complexes
using AI-based methods like AlphaFoldand RoseTTaFold. These advanced
models offer transformative insights into protein structure and
function, but extending their application to larger complexes (more than
two subunits) requires innovative solutions. Our work will focus on:
*
Developing strategiesto predict high-quality structure models for
large biomacromolecular complexes.
*
Cataloguing biomolecular interactionsin the human proteome.
*
Enhancing these datasets using Knowledge Graph (KG) techniquesto
provide enriched structural and functional annotations. This will
enable more efficient data interpretation and knowledge transfer
between related proteins.
The methods developed will be tested in collaboration with researchers
at EMBLand SciLifeLabcryo-EM and integrative structural biology
facilities, ensuring real-world applicability to a broad research community.
Location and Duration
*
Primary Location: EMBL-EBI, Cambridge, UK
*
Regular collaborations and visits to SciLifeLab, Stockholm,
Swedenare expected.
*
The position is for 3 years.
Application
Please send a two-page CV and a two-page project proposal within the
area outlined above to Sameer Velankar at sam...@ebi.ac.ukby November 5,
2024.
The two-page proposal should cover the following areas -
*
Background, proposed project
*
Expected results & their impact
*
Service to be offered
*
Consideration of FAIR principals
This is a pre-proposal. In the second step, we will select one candidate
by November 12 at the latest, and together with the candidate, we will
submit a full proposal by the deadline for the ARISE2 call on November 25.
Contacts:
More information about the ARISE2 program can be found at
https://www.embl.org/training/arise2/
*
For this application
o
Marta Carroni <marta.carr...@scilifelab.se>
o
Sameer Velankar <sam...@ebi.ac.uk>
o
Arne Elofsson <a...@bioinfo.se>
*
For questions about the ARISE2 program
o
ari...@embl.org
*
--
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Deborah Harrus, Ph.D.
PDBe Archive Project Leader, Biocuration Lead
PDBe - Protein Data Bank in Europe
European Bioinformatics Institute (EMBL-EBI)
European Molecular Biology Laboratory
Wellcome Trust Genome Campus
Hinxton
Cambridge CB10 1SD UK
http://www.PDBe.org
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