Dear community Please see below postdoctoral position available in my lab to perform structure-guided engineering of antibody-type modulators of ion channels.
Cheers, Paul Applications are invited for a BBSRC-funded postdoctoral (research associate) position (2-years in the first instance) in the laboratory of Dr Paul Miller at the Department of Pharmacology, University of Cambridge, beginning from around October 2020. The project will focus on studying the molecular basis of antibody modulation of ion channel function and applying structure-guided approaches to engineer unique pharmacological profiles. This research is vital to define the roles of specific ion channel subtypes in CNS physiology and disease and to create new therapeutic modalities. This is a great opportunity to nurture skills in electrophysiology, cryo-EM and structure-guided antibody engineering, ideal for follow-on academic and biotechnology careers. The lab utilises both manual and automated electrophysiology equipment, diverse mammalian cell protein expression systems and purification technologies, and cryo-EM via Arctica and Krios microscopes with Falcon 3/K2/K3 direct detectors. More information about the laboratory is available at https://www.phar.cam.ac.uk/research/miller. The applicant must hold a PhD with relevant experience. Experience in ion channel structural biology/pharmacology and/or electrophysiology is preferred. Experience is sought in one or more aspects of molecular biology, protein expression and purification, and structural biology (interpretation of protein structure, X-ray crystallography, cryo-EM). You must be a careful and methodical worker, paying attention to accuracy, be keen to take responsibility as part of a team, and be willing to work in a collaborative environment. You should be self-motivated and able to organise, perform and analyse experiments with minimal instruction. Note that the precise wording of the online advert may be a little different. Application Closing date: 16th July 2021 Project start date: Approximately 1st October 2021 For more details and to apply: https://www.jobs.cam.ac.uk/job/30163/ Informal enquiries about the position can be made to Dr Paul Miller (pm...@cam.ac.uk<mailto:pm...@cam.ac.uk>) For enquiries about the online application process please contact Debbie Stanley, phar...@lists.cam.ac.uk Paul Miller, PhD University Lecturer in Pharmacology Department of Pharmacology University of Cambridge Tennis Court Road Cambridge CB2 1PD +44 1223 761267 https://www.phar.cam.ac.uk/research/miller ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
