Hi Johannes,
this is normal textbook knowledge, which got perverted over time and
misusage. Just check with a serious dictionary like Merrian Webster or
even the Wikipedia (see below).
Best regards,
Xavier
https://www.merriam-webster.com/dictionary/apoenzyme
https://en.wikibooks.org/wiki/Structural_Biochemistry/Enzyme/Apoenzyme_and_Holoenzyme
https://www.biology-online.org/dictionary/Apoenzyme
https://en.wikipedia.org/wiki/Enzyme
On 31/1/18 15:33, Johannes Cramer wrote:
Dear collegues,
a while ago, there was a discussion in the board on the term
apo-structure as a way to descibe a native, free, or unbound protein
(no ligands). I think the conclusion was that an apo-form is a halo
enzyme lacking a cofactor and should not be used as a substitute for
"unbound".
We were recently asked by a reviewer to change "unbound" to "apo" in a
text. We are weighing our options at the moment. Just comply and
change it or "teach" the reviewer something...
Can anyone share experiences with similar situations? Can anyone point
out a publication on the term?
Cheers,
Johannes
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