Dear collegues, a while ago, there was a discussion in the board on the term apo-structure as a way to descibe a native, free, or unbound protein (no ligands). I think the conclusion was that an apo-form is a halo enzyme lacking a cofactor and should not be used as a substitute for "unbound". We were recently asked by a reviewer to change "unbound" to "apo" in a text. We are weighing our options at the moment. Just comply and change it or "teach" the reviewer something... Can anyone share experiences with similar situations? Can anyone point out a publication on the term?
Cheers, Johannes
