the differences are likely to be on the protein surface, and these would make the crystal contacts, i.e. it would be unlikely the protein could crystallise in the same crystal habit. Never say never in crystallisation (i.e. try anything), but I would go for other things first like additives, different crystallisation techniques, temperatures, concentrations etc.
On 27 Dec 2013, at 20:29, Mahesh Lingaraju wrote: > Dear all, > > I was wondering if it sounds logical to use the crystals from a possible > structural homolog as seeds to induce nucleation ? (in terms of overall > sequence, the proteins are considerably different but based on sequence > alignment and structures from other related proteins, it is highly likely the > protein would have the same structure.) > > Please comment if any of you had experience with this. > > Thank you > > Happy holidays :) > > Mahesh
