Hi , Seems to me that crystal packing is not good thats why mosaic diffraction, this might be due to DNA so you can increase diffraction quality by using 1 or 2 nucleotide sticky end DNA for crystallization which can help in crystal packing .
Vandna Kukshal Postdoctral Research Associate Dept. Biochemistry and Molecular Biophysics Washington University School of Medicine 660 S. Euclid, Campus Box 8231 St. Louis, MO 63110