---------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------Funded Access to Automated Crystallization Screening and in plate x-ray analysis
at Grenoble ---------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------
Access to crystallization services at the High Throughput Crystallization Laboratory of the EMBL Grenoble Outstation is supported by the E.C. Funded Biostruct-X project. To apply please go to the Biostruct-X <http://www.biostruct-x.eu/> web page. Selecting "Single application" will open a pane giving access to PP & HTX.
*Application Deadline April 30th.*Starting in April 2013 and in collaboration with ESRF BM14 beamline the services will be extended to include automated evaluation of crystal hits through in plate X-ray experiments. For this purpose,* *crystallization experiments will be performed in specially developed low-background CrystalDirect plates (/Acta Cryst./ 2012. D*68*, 1393-1399). A crystal pointing tool in CRIMS allows user to select through the web the crystals you want to test.
The High Throughput Crystallization ( HTX ) laboratory of the EMBL Grenoble outstation is one of the key platforms of the Partnership for Structural Biology (PSB) <http://www.psb-grenoble.eu/>and is located next to the European Synchrotron Radiation Facility (ESRF) and the Institute Laue Langevin (ILL). This facility offers completely automated crystallization screening in hanging and sitting drop set up at two temperatures (20°C and 5°C). Results together with all experimental parameters are made available to users in real time through the CRystallization Information Management System (CRIMS), which includes fast and convenient web user interfaces providing advanced tools like drop scoring, drop history, navigation through project targets and samples and project summaries and a crystal pointing tool to support automated in plate x-ray diffraction experiments among others. Crystallization plates are made available to users upon requests (typically during their next synchrotron visit) and facilities for crystal mounting and freezing are provided. Since the start of operations the HTX lab in Grenoble has provided crystallization screening to more than 650 scientists.
Best regards Jose A. Marquez -- _________________________________________________________ Jose A. Marquez Ph.D. Team Leader, Head of Crystallization Facility EMBL Grenoble Outstation Postal address: EMBL Grenoble Outstation, 6 Rue Jules Horowitz, BP181 38042 Grenoble Cedex 9, France Delivery address: EMBL Grenoble Outstation, Polygone Scientifique, 6 Rue Jules Horowitz 38000 Grenoble, France Phone +33 (0)476 20 74 25 Fax. +33 (0)476 20 71 99 https://embl.fr/htxlab/ __________________________________________________________
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