Like Jan, I find it very useful to sort out the clear cut cases.
Otherwise it is easy to get things wrong..
But isnt a buried surface area of 720 rather small for a stable
interface? If there is other confirming evidence like 2 diff space
groups then you feel more secure!!
On 09/01/2011 02:27 PM, Yuri Pompeu wrote:
This is regarding Ethan´s point, particularly:
>2) the protein has crystallized as a monomer even though it
>[sometimes] exists in solution as a dimer. The interface
>seen in the crystal is not the "real" dimer interface and
>thus the PISA score is correct.
I see the same exact interface in a crystal of a close homologue that belongs
to a different space group (hexagonal vs tetragonal system)
