Unfortunately the database contains huge bias towards: a) proteins that are easy to make and crystallize b) biologically interesting protein families
Artem --- When the Weasel comes to give New Year's greetings to the Chickens no good intentions are in his mind. -----Original Message----- From: CCP4 bulletin board [mailto:ccp...@jiscmail.ac.uk] On Behalf Of Edward A. Berry Sent: Wednesday, February 25, 2009 3:49 PM To: CCP4BB@JISCMAIL.AC.UK Subject: Re: [ccp4bb] protein folds As an outsider to this field, it would seem another way to approach it would be to ask, of the currently known folds, how many have only one member (excluding evolutionarily related protein families)? If a large number of folds have only been sampled once, it is likely that there are others that have not been sampled at all. If every known fold has at least 5 independently-evolved examples solved, then it is less likely that some have been missed. If at this stage there are still many folds with only one known example, then probably in fact many folds are represented by a single protein family, in which case it will be necessary to solve a representative from every family to be sure we're not missing a fold. Paul Emsley wrote: > Jayashankar wrote: >> Dear Folks, > > Dear gmail-user, > >> >> The last novel proteins fold were from the yr 2007(pdb statistics), >> From 2007 to till date no novel fold has been identified, this mean >> the present 1283 fold are the final or >> should I wait, if so , with what criteria do I expect for a new >> fold..or what are the expectations ... [snip] > > > Here's an experiment: > > Find a blindfold and put it on. Oh, but before you do that, take a > map of England and place it on a dartboard. > > Now take 56066 darts and throw them at the map on the board. > > Take off the blindfold and investigate where the darts hit. Did you > hit all the towns and cities? You hit London, Birmingham and Leeds > almost certainly. But what about Brighton, did you get that? How > about Clitheroe, was that hit? (Does Clitheroe count anyway or is > that just another part of Preston?) > > I hope that that provides you some with insight. > > Paul. >
