As an outsider to this field, it would seem another way to approach it
would be to ask, of the currently known folds, how many have only one
member (excluding evolutionarily related protein families)?
If a large number of folds have only been sampled once, it is likely
that there are others that have not been sampled at all. If every known
fold has at least 5 independently-evolved examples solved, then it is
less likely that some have been missed.
If at this stage there are still many folds with only one known example,
then probably in fact many folds are represented by a single protein
family, in which case it will be necessary to solve a representative from
every family to be sure we're not missing a fold.
Paul Emsley wrote:
Jayashankar wrote:
Dear Folks,
Dear gmail-user,
The last novel proteins fold were from the yr 2007(pdb statistics),
From 2007 to till date no novel fold has been identified, this mean
the present 1283 fold are the final or
should I wait, if so , with what criteria do I expect for a new
fold..or what are the expectations ... [snip]
Here's an experiment:
Find a blindfold and put it on. Oh, but before you do that, take a
map of England and place it on a dartboard.
Now take 56066 darts and throw them at the map on the board.
Take off the blindfold and investigate where the darts hit. Did you
hit all the towns and cities? You hit London, Birmingham and Leeds
almost certainly. But what about Brighton, did you get that? How
about Clitheroe, was that hit? (Does Clitheroe count anyway or is
that just another part of Preston?)
I hope that that provides you some with insight.
Paul.
