The PISA tool at the EBI can calculate surface area contact, interacting residues and salt bridges/hydrogen bonds between proteins and lots of other things. And it's easy to use.

http://www.ebi.ac.uk/msd-srv/prot_int/pistart.html

Alan



Skrzypczak-Jankun, Ewa wrote:
What is the best and user-friendly program to calculate a surface of the interface between two proteins? Or two domains?

Is there any common criteria how to define boundary for that interface (other than van der Waals distance)?

Thanks in advance for good tips - Ewa

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Dr Ewa Skrzypczak-Jankun Associate Professor

University of Toledo Office: Dowling Hall r.2257

Health Science Campus Phone: 419-383-5414

Urology Department Mail Stop #1091                  Fax:      419-383-3785

3000 Arlington Ave. e-mail: [EMAIL PROTECTED] <mailto:[EMAIL PROTECTED]>

Toledo OH 43614-2598 web: http://golemxiv.dh.meduohio.edu/~ewa

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--
Alan Cheung
Gene Center
Ludwig-Maximilians-University
Feodor-Lynen-Str. 25
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Germany
Phone:  +49-89-2180-76845
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