Dear Brenda,
I am running co crystallisation experiments and have thus far been
trying under
oil screens with some success (i.e. various hits in various conditions
resulting in crystal growth). These conditions have varied from
the native
condition up until now.
Do you already have the structure of the native form? If so, you can
look at the putative binding region of your ligand, and check whereas
it is involved in crystal packing or not. In any case, you'll have to
shoot them and look at the density for confirmation; but just to have
an idea of what "worth can be expected".
HTH
Kind regards.
Leo
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Chavas Leonard, Ph.D.
Research Associate
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Faculty of Life Sciences
The University of Manchester
The Michael Smith Building
Oxford Road
Manchester Lancashire
M13 9PT
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Tel: +44(0)161-275-1586
e-mail: [EMAIL PROTECTED]
