Hello all, I am expecting a somewhat homogeneous reply to this one, but that is fine and welcomed as are anecdotal experiences.
I am running co crystallisation experiments and have thus far been trying under oil screens with some success (i.e. various hits in various conditions resulting in crystal growth). These conditions have varied from the native condition up until now. I have recently peered at some fairly old plates I set up under hanging drop under native conditions when running a co crystal trial and have found crystals. Their morphology is very similar to the 'native' form. I bit punier than them if I had to push. So, 1. Should I be surprised that co crystals pop up under native conditions or does it entirely depend on the ligand? 2. Is it probably not going to be a co crystal as usually they don't pop up under native conditions? 3. It totally depends and if I don't like it then I should get out of this beautiful game? I am going to shoot them either way, but just thought I would ask. cheers Brenda
