Don't call them "co-crystals" until you've actually shot them and seen
the density.
It will depend not only on the ligand but on the ligor(?) as well.
You don't mention the identity of your ligand or ligor(?). You mention
that some of your screens are under oil, so I will point out that some
non-polar ligands might prefer to partition in the oil rather than the
mother liquor. That would explain why the crystals look so much like the
native.
Posting to the BB is always a valuable way to fill time until you can
collect the data which will answer the question.
Cheers,
-
=======================================================================
With the single exception of Cornell, there is not a college in the
United States where truth has ever been a welcome guest - R.G. Ingersoll
=======================================================================
David J. Schuller
modern man in a post-modern world
MacCHESS, Cornell University
[EMAIL PROTECTED]
On Tue, 2008-01-22 at 19:33 +0000, Brenda Patterson wrote:
> Hello all,
>
> I am expecting a somewhat homogeneous reply to this one, but that is fine and
> welcomed as are anecdotal experiences.
>
> I am running co crystallisation experiments and have thus far been trying
> under
> oil screens with some success (i.e. various hits in various conditions
> resulting in crystal growth). These conditions have varied from the native
> condition up until now. I have recently peered at some fairly old plates I
> set
> up under hanging drop under native conditions when running a co crystal trial
> and have found crystals. Their morphology is very similar to the 'native'
> form. I bit punier than them if I had to push.
>
> So,
>
> 1. Should I be surprised that co crystals pop up under native conditions or
> does it entirely depend on the ligand?
>
> 2. Is it probably not going to be a co crystal as usually they don't pop up
> under native conditions?
>
> 3. It totally depends and if I don't like it then I should get out of this
> beautiful game?
>
> I am going to shoot them either way, but just thought I would ask.
>
>
> cheers
>
> Brenda
