I'm currently using qmail + qmail-scanner.
The messages are sent to the sophie process as they arrive - I allow 150+ connections per second, so instead of forking 150 sweeps per message I just use one deamon (sophie).
The messages are received by qmail-smtp, are sent to qmail-scanner which passes them through spamassassin (spamc+spamd) and sohpie.
If you need any help on this setup, contact me off-list, I'd be glad to help.
Regards,
Ricardo Oliveira
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