An update, after about a day of uptime with usb autosuspend DISABLED I have encountered this same issue. This time the issue occured when launching a game, however usually it just randomly fails.
I have attached the dmesg log, at the end I disconnected and reconnected the usb interface but it does not power on at all after reconnecting and outputs device descriptor read errors. ** Attachment added: "dmesg" https://bugs.launchpad.net/ubuntu/+source/linux/+bug/1877887/+attachment/5370405/+files/dmesg -- You received this bug notification because you are a member of Ubuntu Bugs, which is subscribed to Ubuntu. https://bugs.launchpad.net/bugs/1877887 Title: [USB-Audio - Scarlett 2i2 USB, playback] fails after a while To manage notifications about this bug go to: https://bugs.launchpad.net/ubuntu/+source/linux/+bug/1877887/+subscriptions -- ubuntu-bugs mailing list ubuntu-bugs@lists.ubuntu.com https://lists.ubuntu.com/mailman/listinfo/ubuntu-bugs