I'll add that I've got the same issue; the settings slider has no effect on the mouse speed (ThinkPad USB Laser Mouse).
I solved it by removing the following package (NOT RECOMMENDED, MAY BREAK YOUR SYSTEM): xserver-xorg-input-libinput This introduced a new issue described here: https://askubuntu.com/questions/904707/sound-indicator-system-slider- jumps-in-steps-of-10 -- You received this bug notification because you are a member of Ubuntu Bugs, which is subscribed to Ubuntu. https://bugs.launchpad.net/bugs/1682193 Title: Mouse acceleration significantly reduced after upgrade to 17.04 To manage notifications about this bug go to: https://bugs.launchpad.net/ubuntu/+source/xinput/+bug/1682193/+subscriptions -- ubuntu-bugs mailing list ubuntu-bugs@lists.ubuntu.com https://lists.ubuntu.com/mailman/listinfo/ubuntu-bugs