Unrelated to yes/no, I feel like we should dig into why it makes a big difference.
In theory lazy symbol lookup should take care of the big cost associated with it. Disabling the partial relro for libc/libterminfo/libedit/sh did not seem to make a noticeable difference, so I guess it is not so bad. I played with it a bit, and it looks like the biggest difference I got was by setting LC_ALL=C as opposed to LC_ALL=en_US.UTF-8.
