You say "MIMEDefang milter" which I take to indicate that you're using sendmail as your MTA. Sendmail has a built-in ability to use DNSBL and access databases to enable spam control based upon hostname & IP addresses.
Of course, basing your entire decision on a DNSBL is heavy-handed and defeats the idea of SA not using any single criteria to mark a message as spam.
OTOH, if the objective is to reduce cost of the server, you could use MIMEDefang to do only DNSBL checks on mail above some size, on the assumption that it's an acceptable expense to run SA on small messages.
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