I find it interesting that no mention is made of the form of silver used,
the quality of water, why the rats were fed such an unnatural diet  and
the occasion for such a study. More interesting for what it doesn't say
than for what it does.

Al Davis

----- Original Message ----- 
From: "David Bearrow" <[email protected]>
To: <[email protected]>
Sent: Saturday, December 06, 2003 11:39 AM
Subject: CS>Alleviation of silver toxicity by selenite


> I found the following study to be of interest:
>
>
> Alleviation of silver toxicity by selenite in the rat in relation to
tissue
> glutathione peroxidase
>
> PA Wagner, WG Hoekstra and HE Ganther
>
> Dietary Se (0.5 ppm Se supplied as sodium selenite to a casein-based diet
> containing 0.02 ppm Se and lacking in vitamin E) prevented the growth
> depression observed in rats receiving 76 ppm Ag in the water supply and
> markedly improved growth and survival of those given 751 ppm Ag. The Ag
> concentration of liver and possibly of kidney was increased by Se. Liver
> glutathione peroxidase activities from rats fed 0.5 ppm Se and given 76
and
> 751 ppm Ag for 52 days in their water were, respectively, 30% and 4% of
> those from control rats fed 0.5 ppmSe without Ag. In rats fed a diet,
> adequate in vitamin E (100 IU/kg) and Se (0.5 ppm as sodium selenite),
> administration of 751 ppm Ag in the water for 15 wk reduced liver GSH-Px
> activity to 5% of that from control rats receiving no Ag. GSH-Px activity
> of erythrocytes and kidney was decreased by Ag to 37% and 38%,
> respectively, of control values. It is concluded that in vivo
> administration of Ag dramatically decreased liver GSH-Px in rats fed
> Se-supplemented diets with or without vitamin E. Furthermore, supplemental
> Se (0.5 ppm) prevented the growth depression and mortality caused by Ag in
> rats fed a diet lacking vitamin E, while increasing the Ag concentration
of
> liver and kidney.
>
>
> Proceedings of the Society for Experimental Biology and Medicine, Vol 148,
> 1106-1110, Copyright © 1975 by Society for Experimental Biology and
Medicine
>
>
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> ¦              David Bearrow             ¦
> ¦          [email protected]          ¦
> +----      Phone: (972)722-8319      ----+
>
>
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