Hi,
From a purely technical point of view, you can use TIME in your $ERROR
record if you want to implement your drug effect as a direct effect on
top of the circadian rhythm (this type of model may or may not
appropriate, I leave you judge of that).
SinfS = ( 1 + Amplitude * sin ( (2*PI/Peri
Hi,
This might appear like a very naive question but I could not find the
information in the NONMEM use guide: what is the value of the objective
function for ITS, IMP, SAEM, and BAYES estimation methods in relation to
the log likelihood? Is it the standard minus 2 times the log likelihood
li
com>
[mailto:owner-nmus...@globomaxnm.com] On Behalf Of sbihorel
Sent: Monday, January 16, 2017 3:13 AM
To: nmusers@globomaxnm.com <mailto:nmusers@globomaxnm.com>
Subject: [NMusers] Objective function
Hi,
This might appear like a very naive question but I could not find the
information in the NONMEM us
Thanks
On 1/16/2017 5:21 PM, Leonid Gibiansky wrote:
no, you have to run some other method (e.g, FOCEI or IMP in evaluation
mode) to get OF suitable for the tests.
On 1/16/2017 4:24 PM, sbihorel wrote:
Thanks a lot Robert, Leonid, and Nick for your responses.
One follow-up question based
