[NMusers] data splitting/interoccasion variability

opment set + a random sample out of the remaining 60 patients?). I am looking forward to your comments. Best regards, Andreas. ____ Andreas Lindauer University of Bonn Department of Clinical Pharmacy An der Immenburg 4 D-53121 Bonn phone:+49 2

[NMusers] Visual predictive check!

? I would like to know how the more experienced NMusers handle this. Thanks in advance, Andreas. Andreas Lindauer University of Bonn Department of Clinical Pharmacy An der Immenburg 4 D-53121 Bonn phone:+49 228 73 5781 fax: +49 228 73 9757

RE: [NMusers] PPC

. Andreas Lindauer University of Bonn Department of Clinical Pharmacy An der Immenburg 4 D-53121 Bonn phone:+49 228 73 5781 fax: +49 228 73 9757

Re: [NMusers] Simultaneous vs sequential for modeling parent AND metabolites in pop PK

. Regards, Andreas. ________ Andreas Lindauer Department of Clinical Pharmacy Institute of Pharmacy University of Bonn An der Immenburg 4 D-53121 Bonn phone: + 49 228 73 5781 fax: + 49 228 73 9757

RE: [NMusers] OMEGA BLOCK with mixture model?

Nick, In your code example for the estimation of a 'relative bioavailability' wouldn't it be necessary to use a logit transformation to keep F1 between 0 and 1? Something like: F1 = 1/(1+exp(BSV_F1)) Regards, Andreas. ________ Andreas Lindauer

AW: [NMusers] Problem with HESSIAN

Jacob, I would say you missed the scale parameter for the peripheral compartment. So adding S3=V3 should fix your problem. Regards, Andreas. Andreas Lindauer Department of Clinical Pharmacy Institute of Pharmacy University of Bonn An der Immenburg 4 D-53121

[NMusers] Simulations with/without residual error

(t=0) ) 3. Simulated time of maximal response (eg. Tmax) Thanks and best regards, Andreas. Andreas Lindauer Department of Clinical Pharmacy Institute of Pharmacy University of Bonn An der Immenburg 4 D-53121 Bonn phone: + 49 228 73 5781 fax

AW: [NMusers] Simulations with/without residual error

eck (visual, numerical, statistical) that will be compared to distribution statistics of the observations then you should include residual error. Nick andreas lindauer wrote: > > Dear NMUSERS, > > > > The recent discussion about simulation with a nonparametric method

Re: [NMusers] Problem with handling BQL with M3 - additive & proportional error

limit using NONMEM VI,” Journal of Pharmacokinetics and Pharmacodynamics 35, no. 4 (August 2008): 401-421. Just that the right people get their merits... Best regards, Andreas. Dr. Andreas Lindauer Modeling & Simulation and in vivo ADME Dept. of Pharmacokinetics and Metabolism R&

[NMusers] PharmPK Senior PK position in Barcelona, Spain

Senior PK position We are a leading pharmaceutical company with several research centers throughout Europe. Our company focuses on the discovery and development of innovative medicines in the area of cardiovascular, central nervous system, infectious diseases, dermatology and inflammation. We have

RE: [NMusers] Simulate with ETAs from .phi and residual variability

Dear Philp, You may also want to have a look at the open-source R package campsis (https://calvagone.github.io/). Below is some R-code that illustrates how you can easily simulate individual profiles taking the ETAs from a NONMEM output table. Best regards, Andreas. --