Nick,
In your code example for the estimation of a 'relative bioavailability' wouldn't it be necessary to use a logit transformation to keep F1 between 0 and 1? Something like: F1 = 1/(1+exp(BSV_F1)) Regards, Andreas. ____________________________ Andreas Lindauer Department of Clinical Pharmacy Institute of Pharmacy University of Bonn An der Immenburg 4 D-53121 Bonn phone: + 49 228 73 5781 fax: + 49 228 73 9757