1
Y=CUMD
ENDIF
$THETA
-1.868;[KA]
11.9 ;[V]
10;[CL]
0.523;[SD]
$OMEGA
0.258
0.177
0.227
$SIGMA
1 FIX
$EST METHOD=COND LAP INTERACTION MAXEVAL= PRINT=5 FILE=PK.LOG.COND.ext
Sample Data for code 1:
Sample Data for code 2:
Best regards,
Xiao Hu (Shelley), Ph.D.
Scientist
:
$THETA
12 ;THETA5
8.89 ;THETA6
0.0015;THETA8
0.263 ; THETA9
2.87; THETA11
Best regards,
Shelley
========
Xiao Hu (Shelley), Ph.D.
Scientist,
Development Pharmacokinetics & Disposition
Biogen Idec, Inc.
14 Cambridge Center
Cambridge, MA 02142
DED.
Best regards,
Shelley
====
Xiao Hu (Shelley), Ph.D.
Scientist,
Development Pharmacokinetics & Disposition
Biogen Idec, Inc.
14 Cambridge Center
Cambridge, MA 02142
Luann Phillips
10-Aug-2010 01:29 PM
Message Size: 6.6 KB
To
Xiao Hu
cc
nmusers
Sub
first. It's work in
progress.
3. ALAG may have caused problem, especially with differential equation,
along with ETA.
Best regards,
Shelley
========
Xiao Hu (Shelley), Ph.D.
Scientist,
Development Pharmacokinetics & Disposition
Biogen Idec, Inc.
14 Ca
Ann,
Because you already log-tranformed your data, you may want to change
SIG1*IPRED to SIG1 for DUM.
I'm guessing the combination of ALAG and SIG1*IPRED is causing problem.
DUM = (LOQ-IPRED)/(SIG1)
Best regards,
Shelley
Xiao Hu (Shelley),
Dear Graduate candidates,
We have a summer internship in Biogen Idec for an M&S project. It's
posted at ACOP website. For more details, please visit
http://www.go-acop.org/2011/job-postings.
Best regards,
Shelley
====
Xiao Hu (Shelley), Ph.
g for an answer for my IT rep for two weeks and am
wondering if I can get some guidance from our discussion group.
Best regards,
Shelley
Xiao Hu (Shelley), Ph.D.
Senior Scientist,
Clinical Pharmacology and Pharmacometrics
Biogen Idec, Inc.
14 Camb
, and fixed the system environment
variables. Now I'm able to run NONMEM in both DOS command window and R.
Best regards,
Shelley
Xiao Hu (Shelley), Ph.D.
Senior Scientist,
Clinical Pharmacology and Pharmacometrics
Biogen Idec, Inc.
14 Cambridge
,
Shelley
====
Xiao Hu (Shelley), Ph.D.
Senior Scientist,
Clinical Pharmacology and Pharmacometrics
Biogen Idec, Inc.
14 Cambridge Center
Cambridge, MA 02142
Nick Holford
Sent by: owner-nmus...@globomaxnm.com
18-May-2011 05:22 AM
Message Size: 16.7 KB
To
nmusers
cc
Subject
Re: [NMuse
Dear NM users,
I'm working on a PK model in renal disease patients with hemodialysis. The
drug in healthy subjects is well described with a first-order absorption and
one-compartment disposition model. A third hemodialysis compartment was added;
CMT=3 or -3 were included in the data set to tu
AM
To: Xiao Hu
Cc: nmusers@globomaxnm.com
Subject: Re: [NMusers] Modeling Hemodialysis clearance
Xiao Hu,
I think it may be a problem with identifiability. It can't separate the
definition of K23 from K20 unless there are measurements during elimination for
hemo. patients off dialysis a
.com]
Sent: Wednesday, July 20, 2011 12:54 PM
To: nmusers@globomaxnm.com
Cc: Xiao Hu
Subject: Re: [NMusers] Modeling Hemodialysis clearance
Dear Xiao,
I agree with Jun's advise. You previous setting should not work as when you
switch the compartment 3 off nothing changes for compartment 2
ssage-
From: Luann Phillips [mailto:luann.phill...@cognigencorp.com]
Sent: Thursday, July 21, 2011 10:32 AM
To: Xiao Hu
Cc: nmusers@globomaxnm.com
Subject: Re: [NMusers] Modeling Hemodialysis clearance
Xiao Hu,
The concept of turning on/off compartments was presented to me in the contex
Sent: Thursday, July 21, 2011 3:08 PM
To: Xiao Hu
Cc: Bauer, Robert
Subject: FW: [NMusers] Modeling Hemodialysis clearance
Hi Xiao,
If the hemodialysate is being directly analyzed then the ON/OFF feature can be
used as for urine.
However, if the hemodialysate is not being directly analyzed, I a
R can start the next run?
Best regards,
Shelley
=====
Xiao Hu (Shelley)
Senior Scientist
Clinical Pharmacology and Pharmacometrics
Department of Translational Medicine
Biogen Idec,
14 Cambridge Center, Cambridge, MA 02142
Dear Pierre-Olivier,
I think once you defined ALAG(1)=THETA() (as Luann suggested), the system will
delay your input. You don't have to specify anything in the $DES block. It's
worth trying.
$PK
ALAG(1)=THETA()
$DES
DADT(1)=(DOSE/V)*INPUT-K*A(1)
Best regards,
Xiao (Shelley)
-Orig
o:jun.shen...@gmail.com]
Sent: Thursday, July 28, 2011 12:27 PM
To: Xiao Hu
Cc: Tremblay, Pierre-Olivier; Luann Phillips; nmusers@globomaxnm.com
Subject: Re: [NMusers] lagged absorption and empirical input function
Dear all,
This issue is worth a bit more discussion.
My understanding about ALAG is, for ex
Dear NMusers,
I'm working on some Phase 3 PK data, which has >30,000 records. I got an error
message and did not have a clue what it means. I'm wondering if anyone can
give me some suggestions.
Kindest regards,
Xiao
The end of the output from nonmem:
#METH: First Order
MONITORING OF SEARCH:
Dear NMusers,
I'm trying to run simulation using MSF file, but got the following error
message:
"ERROR IN READING FILE : MSF FILE USED BY INEST"
Can anyone give me a hint on what it means and how to fix it? I'd really
appreciate it.
Kindest regards,
Xiao
$PROBLEM PK Model
$INPUT CMM STUDY ID
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