s, setting NREC = 10002 gives the above error.
Doesn't seem related to the size of the file, just the number of records.?
Perhaps this is related to the 4 digits assigned for the length of the data
file in FCON (but then why 10001, not 1)? Anyone know of a work-around?
thanks
Mark
?Bob,
Thanks very much, setting computers = 2 solved it
Mark
Mark Sale M.D.
Vice President, Modeling and Simulation
Nuventra, Inc. (tm)
2525 Meridian Parkway, Suite 280
Research Triangle Park, NC 27713
Office (919)-973-0383
ms...@nuventra.com
www.nuventra.com<http://www.nuventra.
Dear Colleagues,
I'm working on a model of a malignancy that, at some point in the course of
the disease enters into an accelerated phase. I'm using a sort of standard
serial compartment model, with a zero order input rate, then first order
transit to the next compartment. I think the "corre
Thanks to Mannie, this is the correct way to solve this (and seems to work as
well).
Thanks
Mark
From: echigu...@yahoo.com [mailto:echigu...@yahoo.com]
Sent: Friday, May 29, 2015 7:34 PM
To: Mark Sale
Subject: Re: [NMusers] Modeling accelerated phase of malignancy
Hi Mark
Have you tried
Li,
I'm going to go out on a limb (since I haven't seen your data or understand the
biology) and suggest that the baseline value is not a covariate, but is just
another observation (presumably with drug concentration = 0). The baseline
value is sort of by definition a function of kin. So, you
he $TABLE step).
I assume it is crashing calculating the conditional ETAs (don't know why it
does OK in estimation). PRDERR only has the small number of error from the
estimation
Anyone seen this error, any suggestions on how to get rid of it (other than
removeing subject 51)?
Ma
but crashed on tables). Tried FOCE,
IMPMAP as well as SAEM. I did try removing the offending subjects, but just
had the same problem with another (ultimately removed nearly 1/3 of the data,
still had the error). So, ended up just going back to a simpler model.
thank
Mark
Mark Sale M.D.
surprised that I can't find anything about
dosing CNS drugs to peds, based on brain weight (and, ideally, brain
clearance). Does anyone know of anything?
thanks
Mark
Mark Sale M.D.
Vice President, Modeling and Simulation
Nuventra, Inc. (tm)
2525 Meridian Parkway, Suite 280
Research Tri
WRT bootstrap, it makes much more sense to simply bootstrap the many nonmem
runs (start 8 NONMEM runs at at time, rather than 1 run parallelized to 8
cores).
So, no, don't use parallel NONMEM for bootstrap, run multiple bootstrap samples
at the same time.
Mark
Mark Sale M.D.
Nonmem 7.2
estimation methods and parallel ...
Read more...<http://www.ncbi.nlm.nih.gov/pubmed/22101761>
Mark
Mark Sale M.D.
Vice President, Modeling and Simulation
Nuventra, Inc. ™
2525 Meridian Parkway, Suite 280
Research Triangle Park, NC 27713
Office (919)-973-0383
ms...@nuventra.com
www.nuventra
e of the data
set, except that the limit of parallelization is the number of subjects (the
data set must be split up by subject).
Mark Sale M.D.
Vice President, Modeling and Simulation
Nuventra, Inc. ™
2525 Meridian Parkway, Suite 280
Research Triangle Park, NC 27713
Office (919)-973-0383
es, but would look forward
to learning about other peoples experience.
Mark
Mark Sale M.D.
Vice President, Modeling and Simulation
Nuventra, Inc. ™
2525 Meridian Parkway, Suite 280
Research Triangle Park, NC 27713
Office (919)-973-0383
ms...@nuventra.com
www.nuventra.com<http://www.nuventr
completely agree, no reason to use FPI,
Mark Sale M.D.
Vice President, Modeling and Simulation
Nuventra, Inc. ™
2525 Meridian Parkway, Suite 280
Research Triangle Park, NC 27713
Office (919)-973-0383
ms...@nuventra.com
www.nuventra.com<http://www.nuventra.com>
Empower your Pi
it still gave me a very small difference in the
intercept for the 2nd and 3rd populations.
Is there an issue with using mixture models with logistic regression? I'm just
using FOCE, Laplacian, without interaction, and LIKE.
Any ideas?
Mark
Mark Sale M.D.
Vice President, Modelin
imate for omega. If the data are population, and MAXE-
VALS=0 is not coded, then METHOD=1 LAPLACE is required. Compare
with PREDICTION option.
Mark Sale M.D.
Vice President, Modeling and Simulation
Nuventra, Inc. ™
2525 Meridian Parkway, Suite 280
Research Triangle Park, NC 27713
O
(s). If you have received this transmittal in error,
please notify me immediately by reply email and destroy all copies of the
transmittal.
From: Bob Leary
Sent: Saturday, February 20, 2016 9:24 AM
To: Mark Sale; nmusers@globomaxnm.com
Subject: RE: Mixture mod
o the apparent population in the data set.
Mark
Mark Sale M.D.
Vice President, Modeling and Simulation
Nuventra, Inc. ™
2525 Meridian Parkway, Suite 280
Research Triangle Park, NC 27713
Office (919)-973-0383
ms...@nuventra.com
www.nuventra.com<http://www.nuventra.com>
Empower yo
Kudos to Jeroen, who solved this for me, needed the NOINTER option on $EST,
then you can use SAEM, which gave a reasonable answer, unlike FOCE.
Mark
Mark Sale M.D.
Vice President, Modeling and Simulation
Nuventra, Inc. ™
2525 Meridian Parkway, Suite 280
Research Triangle Park, NC 27713
Office
, LAPLACIAN ESTIMATION METHOD MUST BE USED
It seems the Laplacian isn't used for the grid search for initial estimates
(even though specified in $EST).
any ideas?
Mark Sale M.D.
Vice President, Modeling and Simulation
Nuventra Pharma Sciences, Inc.
2525 Meridian Parkway, Suite 280
Durham, NC
pretty standard $EST I think
$ESTIMATION METH=1 NUMERICAL SLOW LAPLACIAN INTER NOTHETABOUNDTEST
NOOMEGABOUNDTEST
MAXEVAL= PRINT=1 NOABORT MSFO=MSF1
and just 1.
Mark Sale M.D.
Vice President, Modeling and Simulation
Nuventra Pharma Sciences, Inc.
2525 Meridian Parkway, Suite 280
thanks Bob
Mark Sale M.D.
Vice President, Modeling and Simulation
Nuventra Pharma Sciences, Inc.
2525 Meridian Parkway, Suite 280
Durham, NC 27713
Phone (919)-973-0383
ms...@nuventra.com
CONFIDENTIALITY NOTICE The information in this transmittal (including
attachments, if any) may be privileged
Is it possible to use a normal prior for OMEGA? The default is inverse Wishart,
but I'd be interested in using Normal (insuring that it is positive definite)
Any ideas?
thanks
Mark Sale M.D.
Vice President, Modeling and Simulation
Nuventra Pharma Sciences, Inc.
2525 Meridian Parkway,
l way to do it.
I'll look into the TNPRI (didn't realize that stood for triple normal, but that
makes sense).
thanks
Mark
Mark Sale M.D.
Vice President, Modeling and Simulation
Nuventra Pharma Sciences, Inc.
2525 Meridian Parkway, Suite 280
Durham, NC 27713
Phone (919)-973-0383
ms.
r than the LRT?
But, basically, why is this happening?
thanks
Mark Sale M.D.
Senior Vice President, Pharmacometrics
Nuventra Pharma Sciences, Inc.
2525 Meridian Parkway, Suite 200
Durham, NC 27713
Phone (919)-973-0383
ms...@nuventra.com
CONFIDENTIALITY NOTICE The information in this transmittal
G JOB TO LOCAL
STARTING SUBJECTS 9 TO 17 ON MANAGER: OK
COLLECTING SUBJECTS 18 TO 32 ON WORKER2
and no mention of collecting subjects 33 to 85 on worker 3, or subjects 9 to 17
on worker 1.
so, that could be the problem.
Bob - thoughts?
Mark Sale M.D.
Senior
MFE73/74 batch file (for deployment reasons,
would prefer not to have to edit the batch file, which would be easy enough to
do, but again, I'd like a general/deployable solution, not a custom .bat
file.). Can this be done, with the unedited version of NMFE??.bat or with PSN?
thanks
Mar
EE etc. Can the SEE values in this case be
believed?
Mark Sale M.D.
Senior Vice President, Pharmacometrics
Nuventra Pharma Sciences, Inc.
2525 Meridian Parkway, Suite 200
Durham, NC 27713
Phone (919)-973-0383
ms...@nuventra.com
MS-MPI offers several benefits:
we need to run this for another parallel application, and when we installed it,
it broke parallel NONMEM. We're using Intel Fortran, 64 bit Window Server
(2012).
thanks
Mark Sale M.D.
Senior Vice President, Pharmacometrics
Nuventra Pharma Sciences, Inc.
25
t clear there is a way to specify which mpiexec to use in a
given application, along with lots of other stuff I don't understand.
Mark Sale M.D.
Senior Vice President, Pharmacometrics
Nuventra Pharma Sciences, Inc.
2525 Meridian Parkway, Suite 200
Durham, NC 27713
Phone (919)-973-0383
ms...@nu
amount of information.
That not withstanding, we also remove and pre-dose BQLs from the data set.
Mark Sale M.D.
Senior Vice President, Pharmacometrics
Nuventra Inc.
2525 Meridian Parkway, Suite 200
Durham, NC 27713
Phone (919)-973-0383
ms...@nuventra.com
CONFIDENTIALITY NOTICE The information in
If >LLOQ has information, then !>LLOQ MUST also have information.
and Yes, we evacuated for 6 days, back home now.
Mark Sale M.D.
Senior Vice President, Pharmacometrics
Nuventra Inc.
2525 Meridian Parkway, Suite 200
Durham, NC 27713
Phone (919)-973-0383
ms...@nuventra.com
CONFIDENT
s of the
transmittal.
From: Stephen Duffull
Sent: Wednesday, November 6, 2019 9:05 AM
To: Dennis Fisher ; Mark Sale
Cc: nmusers@globomaxnm.com
Subject: RE: [NMusers] Using evid 0 before dosing
WARNING: This email originated from outside of the company. Do not click links
e have any experience trying to run v7.4,
ADVAN14 with old Intel Fortran?
thanks
Mark Sale M.D.
Senior Vice President, Pharmacometrics
Nuventra Inc.
2525 Meridian Parkway, Suite 200
Durham, NC 27713
Phone (919)-973-0383
ms...@nuventra.com
CONFIDENTIALITY NOTICE The information in this t
4 bytes free
Base on a search for this error, it looks like it comes from dplyr. I'm running
dplyr version 0.8.4, xpose version 0.4.7 and R version 3.6.2 with R Studio,
under Windows 10.
I've tried it with and without the NOAPPEND in the $TABLE records.
Any suggestions would be apprecia
Bill, thanks
that may be it, seems to be working, thanks
Mark
Mark Sale M.D.
Senior Vice President, Pharmacometrics
Nuventra Inc.
2525 Meridian Parkway, Suite 200
Durham, NC 27713
Phone (919)-973-0383
ms...@nuventra.com
Upcoming Events:
Webinar:<https://www.nuventra.com/resources/eve
ffalo is a collaborator on this work and a
co-investigator for this work. His laboratory has contributed sample datasets
and suggestions on the strategies for model search
Mark Sale M.D.
Vice President
Integrated Drug Development
mark.s...@certara.com
Remote-Forestville CA
Office Hours 9 AM - 5
lp me with the code to do this?
Thanks
Mark
Mark Sale M.D.
Vice President
Integrated Drug Development
mark.s...@certara.com
Remote-Forestville CA
Office Hours 9 AM - 5 PM Eastern Time
+1 302-516-1684
www.certara.com
This message (including any attachments) may contain confidential, propri
ation -keep_tables
I'm thinking that may be easier than trying to use NWPRI.
thanks
Mark Sale M.D.
Vice President
Integrated Drug Development
mark.s...@certara.com
Remote-Forestville CA
Office Hours 9 AM – 5 PM Eastern Time
+1 302-516-1684
www.certara.com
-Original Message-
From:
does prohibit using PROTECT in automated
methods to run models with/without BSV, or at least makes it a little more
difficult.
Mark Sale M.D.
Vice President
Integrated Drug Development
mark.s...@certara.com
Remote-Forestville CA
Office Hours 9 AM - 5 PM Eastern Time
+1 302-516-1684
www.certar
results using Darwin Reporter - hands on using AWS
workspace.
Registration fee: $275 Academic or Regulatory /$550 Industry
Register here:
https://www.certarauniversity.com/store/3646717-page2024-workshop-pmx-analysis-in-r-using-rsnlme-and-certara-toolsets
Mark Sale M.D.
Vice President
Integrated
search results using Darwin Reporter - hands on using AWS
workspace.
Registration fee: $275
Mark Sale M.D.
Vice President
Integrated Drug Development
mark.s...@certara.com
Remote-Forestville CA
Office Hours 9 AM - 5 PM Eastern Time
+1 302-516-1684
www.certara.com
[Certara Logo]
This message
ara-toolsets>
Mark
Mark Sale M.D.
Vice President
Integrated Drug Development
mark.s...@certara.com
Remote-Forestville CA
Office Hours 9 AM - 5 PM Eastern Time
+1 302-516-1684
www.certara.com
[Certara Logo]
This message (including any attachments) may contain confidential, proprietary,
priv
esearch, a testament to both his
technical knowledge and leadership skills. Like many others I personally
benefited from my interactions with him.
Mark
Mark Sale M.D.
Vice President
Integrated Drug Development
mark.s...@certara.com
Remote-Forestville CA
Office Hours 9 AM - 5 PM Eastern Time
+1 30
Dear colleagues,
There's still time to register for the Machine learning Model selection in
NONMEM and NLME at the June Page meeting. Link below:
https://www.certarauniversity.com/store/4230502-page2025-workshop-machine-learning-model-selection-in-nlme-nonmem-with-pirana-and-r
Mark
Mark
Dear colleagues,
Take a look at our Pre conference course at PAGE on PMX tools including
Machine learning model selection
https://www.certarauniversity.com/store/4230502-page2025-workshop-pmx-analysis-in-r-using-rsnlme-pirana-and-certara-toolsets
Mark
Mark Sale M.D.
Vice President
Integrated
Dear Colleagues,
In response to the recent discussion in this forum about sample size
and power in NONMEM, Next Level Solutions has developed tools for
formal "power" assessment in NONMEM using simulation (as described by
Serge Guzy in this discussion). Essentially, one or more (preferably
more)
nical Pharmacology
> Medical Science Sweden
> AstraZeneca R&D Lund
> SE-221 87 Lund, Sweden
>
>
>
Mark Sale MD
Next Level Solutions, LLC
www.NextLevelSolns.com
> Original Message
> Subject: [NMusers] Simulation with covariates
> From: "Kriste
ct, the value of CONC is still
left over from the last subject.
This is all OK for the minimization, you just need to be aware of it
when interpreting output, plots, tables etc. that the first value for
CONC for a subject will not be correct.
Mark
Mark Sale MD
Next Level Solutions, LLC
www.Next
PROBS.
Mark Sale MD
Next Level Solutions, LLC
www.NextLevelSolns.com
>
>
> > Original Message
> > Subject: Re: [NMusers] create simulation file for 5000 patients ?
> > From: "navin goyal" <[EMAIL PROTECTED]>
> > Date: Tue, Februar
hey went out of business), and got zero
parallelization for a single run of NONMEM. But this was a long time
ago, maybe Intel figured out something new.
Mark
Mark Sale MD
Next Level Solutions, LLC
www.NextLevelSolns.com
> Original Message
> Subject: Re: [NMusers] Linear sp
Brian,
Windows will switch which processor/core it is running any executable
on (unless you explicity tell it to run on a specific processor/core).
But the total CPU time should be 100% (even if it is 25% on each of 4
processors).
Mark
Mark Sale MD
Next Level Solutions, LLC
point out that it is not nearly that linear a process,
although in figure 11.1, Vol 5 of the NONMEM manuals, it is depicted as
a step-by-step algorithm, without any looping back). Can anyone point
me to any rigorous discussion of this model building strategy?
Mark Sale MD
Next Level Solutions, LLC
www.NextLevelSolns.com
once you've found it. I'm interest in how we find
it.
Mark Sale MD
Next Level Solutions, LLC
www.NextLevelSolns.com
> Original Message
> Subject: RE: [NMusers] General question on modeling
> From: "Stephen Duffull" <[EMAIL PROTECTED]>
> D
nly is no single criteria by which to evaluate the
models, must be purpose specific.
Mark Sale MD
Next Level Solutions, LLC
www.NextLevelSolns.com
> Original Message
> Subject: RE: [NMusers] General question on modeling
> From: "Stephen Duffull" <[EMAIL PROTEC
g a
label requiring them to do so would not result in an optimal outcome.
(I won't defend ITT analysis, although I do appreciate that the origin
of ITT is in another optimization issue, wherein type II errors are
greatly prefered to type I errors in testing hypotheses, I likely would
have a d
f
mis-dosing drugs, and estimated the resulting fatalities. Making
dosing more complicated is unlikely the help. In addition, each
company very much wants their drug to be simpler to use than their
competitors.
Mark Sale MD
Next Level Solutions, LLC
www.NextLevelSolns.com
> Original
it is the structural model that drives pretty much everything. It
matters more if you chose an Emax over an indirect response for your PD
model than whether you put age as a predictor of Emax.
Mark
Mark Sale MD
Next Level Solutions, LLC
www.NextLevelSolns.com
> Original
the structural
model (which attempts to explain away the effect of time). Interesting
insight from Allison on why the variance terms ended up last in the
algorithm.
Mark
Mark Sale MD
Next Level Solutions, LLC
www.NextLevelSolns.com
> Original Message
> Subject: Re: [NMus
> Subject: RE: [NMusers] General question on modeling
> From: "Wang, Yaning" <[EMAIL PROTECTED]>
> Date: Tue, March 20, 2007 1:33 pm
> To: "Mark Sale - Next Level Solutions" <[EMAIL PROTECTED]>,
> nmusers@globomaxnm.com
>
> In Marie Davidian
e certainly not true. But, evolutionary computation
and machine learning is a very different approach (and IMHO a more
rigorous approach) than what we currently do.
Mark Sale MD
Next Level Solutions, LLC
www.NextLevelSolns.com
> Original Message
> Subject: Re: [NMusers] Ge
you try
to find the offending record in the data set (the NRECORDS option should
help). Hopefully we'll hear from Alison (isn't it great to have her
back?)
Mark
Mark Sale MD
Next Level Solutions, LLC
www.NextLevelSolns.com
> Original Message
> Subject: [NMuse
a set, and will only write legal data sets. If it makes it past
NMTRAN, it has a legal (if not correct) data set.
Mark Sale MD
Next Level Solutions, LLC
www.NextLevelSolns.com
> Original Message
> Subject: RE: [NMusers] input conversion error
> From: "Bachman, Wil
and saving.
WRT plots, two options are Xpose from the Upsala group (R/Splus,
http://xpose.sourceforge.net) or an excel macro from Next Level
Solutions (www.nextlevelsolns.com)
Mark Sale MD
Next Level Solutions, LLC
www.NextLevelSolns.com
> Original Message
> Subject:
Thanks for clarifying this Alison, I think I did know this is a fortran
I/O issue, not really a NMTRAN issue. Clearly we should all go back to
MS-DOS edit ;-) (only us really old people even remember MS-DOS).
Mark Sale MD
Next Level Solutions, LLC
www.NextLevelSolns.com
> Origi
the first line of c:\nmvi\util\nmfe6.bat
type c:\nmvi\util\end.txt >> %1
Mark Sale MD
Next Level Solutions, LLC
www.NextLevelSolns.com
> Original Message
> Subject: RE: [NMusers] No Fit file -> bug or not a bug?
> From: "Bill Bachman" <[EMAIL
: the Livermore solver, from the ODEPACK.
and, no, I'm pretty sure there is no switching between algorithms. (does
any software do this??)
BTW, no one ever answered my question from 2 years ago.
Mark Sale
Next Level Solutions, LLC
www.NextLevelSolns.com
> Original
alty, to keep it out of that range again)?
Mark
Mark Sale MD
Next Level Solutions, LLC
www.NextLevelSolns.com
> Original Message
> Subject: Re: [NMusers] NONMEM ODE solver
> From: "Alison Boeckmann" <[EMAIL PROTECTED]>
> Date: Mon, May 28, 2007
here again (at least right away).
Mark
Mark Sale MD
Next Level Solutions, LLC
www.NextLevelSolns.com
> Original Message
> Subject: RE: [NMusers] NONMEM ODE solver
> From: "Alison Boeckmann" <[EMAIL PROTECTED]>
> Date: Tue, May 29, 2007 2:09 pm
&
d.
It doesn't look like the iteration number is available in PK, but you
have it in this file with the standard NONMEM output.
Mark Sale MD
Next Level Solutions, LLC
www.NextLevelSolns.com
> Original Message
> Subject: [NMusers] How to generate an output file with individua
Dear Colleagues, I've created a Windows application for summarizing NONMEM output file, called nmsee2 (after the original NMSEE). I've put the setup files on the Next Level Solutions web site (http://www.nextlevelsolns.com/downloads.html, near the bottom). This application was written to extrac
Colleagues, Is anyone aware of any data (general or specific) on pd relationships for monoclonal antibodies? Especially things like AUC vs Cmax for drugs like anti TNF.thanksMark Sale MDNext Level Solutions, LLCwww.NextLevelSolns.com
Wei-jian The error message means exactly what it says, you have, in the $MODEL record more than one compartment labeled as DEFOBS (compartments 2 and 6). Probably you don't want/need any compartment as the default dose or observation, but rather should be explicitly saying which compartment any d
SETUP.TXT, from the NONMEM home directory.The Introduction to NONMEM VI does alert the user that there are newerror messages but does not provide the details. This response will becopied to nmusers so that users are better informed.Thank you for your message.Tom Ludden Mark Sale MDNext Level
t] or failure to converge) I don't hesitate to remove it. I don't see a reason to treat variance parameters any different from structural model parameters or co!
variate parameters in this regard.Mark
Mark Sale MDNext Level Solutions, LLCwww.NextLevelSolns.com
Original Message
Dear Colleagues, The windows based NONMEM output viewer described earlier has been updated, with bug fixes. Bug fixes are that it now correctly handles SAME blocks and handles missing files and files that are not NONMEM output files correctly. Additional features include printing out SE of estim
ecially if one checks both a point
estimate (AUC, Cmax, Cmin) and some measure of variability (SE of AUC
etc), since an artificially large variability can fool PPC.
Mark Sale MDNext Level Solutions, LLCwww.NextLevelSolns.com
Original Message
Subject: Re: [NMusers] Minimization
n't bother us to admit that sometimes we can't identify a compartment sometimes, when in reality we can only identify a tiny fraction of the true biological compartments. Mark Sale MDNext Level Solutions, LLCwww.NextLevelSolns.com
Original Message
Subject: [NMusers]
ions (http://www.nextlevelsolns.com/downloads.html) does delete records where MDV <> 0, if you include this in the $TABLE output. Mark Sale MDNext Level Solutions, LLCwww.NextLevelSolns.com
Original Message
Subject: [NMusers] Model Comparison and Viewing of Output
From: Nit
Colleagues, I suspect I'm not the only one who has, over the years had the experience of spending a week (or more) on an analysis only to find important errors in the data set. I'm hoping for some feedback on what people do to try to find these errors (short of spending a week on an incorrect da
vel Solutions, LLCwww.NextLevelSolns.com919-846-9185
Original Message
Subject: RE: [NMusers] Data checking macro
From: "Bill Bachman" <[EMAIL PROTECTED]>
Date: Thu, September 13, 2007 3:48 pm
To: "'Mark Sale - Next Level Solutions'" <[EMAIL PROTEC
ale MDNext Level Solutions, LLCwww.NextLevelSolns.com919-846-9185
Original Message
Subject: RE: [NMusers] Data checking macro
From: "Bill Bachman" <[EMAIL PROTECTED]>
Date: Thu, September 13, 2007 4:35 pm
To: "'Mark Sale - Next Level Solutions'"
Sam, I think you should have gotten the error:INITIAL ESTIMATE OF OMEGA HAS A NONZERO BLOCK WHICH IS NUMERICALLY NOT POSITIVE DEFINITEwhich is the case. (you can check this in Excel, using the MDETERM function, the determinant is -2945). When you get this message, try reducing the off-diagonal e
Nick, I think, in the big picture, it is important to remember why we do all this. It isn't for our own entertainment, or to congratulate each other on how insightful we are. It is to provide useful information to providers. We are not (we hope) the real audience for our work. It probably isn'
eignevalues are, allometric scaling is great, if it is people who have 12 minutes to examine,
> diagnose and treat a patients, maybe we can keep it simple. Doing otherwise puts use are risk for
> irrelevance.
>
>
>
> Mark Sal
-9185
Original Message
Subject: RE: [NMusers] Reporting Modeling Results
From: "Stephen Duffull" <[EMAIL PROTECTED]>
Date: Thu, October 25, 2007 6:52 pm
To: "'Mark Sale - Next Level Solutions'" <[EMAIL PROTECTED]>
Cc: "'nmusers&
phen Duffull" <[EMAIL PROTECTED]>
Date: Fri, October 26, 2007 2:56 pm
To: "'James G Wright'" <[EMAIL PROTECTED]>, "'Mark Sale - Next
Level Solutions'" <[EMAIL PROTECTED]>
Cc: "'nmusers'"
James, Mark
I don't have tim
modeling to select dosing regimens, and finish with a purely regulatory and marketing piece of work that I'm familiar with:http://www.aesnet.org/Visitors/AnnualMeeting/A!
bstracts/dsp_Abstract.cfm?id=2578(this got published as a real article, but I can't find a link to the paper).Mark Sa
Nick, Tacrine, My understanding (correct me if I'm wrong), was that the traditional analysis was unconvincing wrt efficacy and the model you developed ultimately helped justify approval. Presumably, some patients had an improved outcome from the use of the drug. My experience with end of phase I
I think I recently saw a thread about this, but is there a way to fix the bug/feature where NONMEM v6 gives this message:0THE SIMULATION TASK REQUIRES THAT A BETTER FINAL ESTIMATE BE AVAILABLE IN THE MODEL SPECIFICATION FILEand will do a simulation with an MSF regardless?thanksMarkMark Sale MD
Nex
Joachim, This is probably a file access error, from Fortan/OS, not from NONMEM. Does NMTRAN run? Does the compiler run? Does nmlink6 run (do you get link.lnk)? Do you get an executable? Does NONMEM start then stop? If you get the executable (nonmem.exe or fsubs.exe), then the error is with fi
ut, how do you explain that the same models reformulated with ANDAN6 run? Well, they take very long... and none of them has run to a successful minimization yet. Joachim Mark Sale - Next Level Solutions <[EMAIL PROTECTED]> 07.12.2007 13:44 To [EMAIL PROTECTED] cc nmusers@globomax
annot open these file. It doesn't (usually) happen with the original data set, unless you try to run NMTRAN simultaneously. Mark Sale MD
Next Level Solutions, LLC
www.NextLevelSolns.com
919-846-9185
Original Message
Subject: RE: [NMusers] error (157) forrtl: severe
From: "
I'm thinking of doing a somewhat formal analysis of the meaning of a failed covariance step. Some years ago Stu Beal explained that (as I recall), if the covariance step fails you cannot be sure that the minimum isn't a saddle point, which makes sense to me, and is consistent (I think), with the
l?
From: Leonid Gibiansky <[EMAIL PROTECTED]>
Date: Tue, January 29, 2008 12:37 pm
To: Mark Sale - Next Level Solutions <[EMAIL PROTECTED]>
Cc: nmusers@globomaxnm.com
Hi Mark
I am pretty confident (although I do not have a proof) that all (or all
reasonably good, meaning that you i
Jin, Another options it the Fortran app nmsee (ftp://ftp.globomaxnm.com/Public/nonmem/nmsee/)or a version of nmsee I recently put together (cleverly called nmsee2) at http://www.nextlevelsolns.com/downloads.html. These are both post-processors that read the NONMEM output file (and so you only g
Rik, I don't know anything about the non-parametric estimates: 'expected value of ETA' and
'Covariance matrix of ETAI. But, think the correlation matrix is CORRM in COMMON /CM12/ COVM(LPAR3),COVINM(LPAR3),STHTA(LTH),SEN(LVR,LVR), 1 CORRM(LPAR3),NVLS,VLS(LPAR)and you can get
Heiner, Your solution works really nicely - can't figure out why mine doesn't. BTW, you can use (at least in Windows) an absolute reference to the SIZES file
INCLUDE 'C:\NMVI\SIZES'also, I think you may need to assign a value to the filename CHARACTER*16 FILECOV FILECOV = 'COVOUT
Rik, It isn't pretty (but what Fortran is?, wouldn't be Fortran without a GOTO) but this seems to work. The previous wasn't working because I didn't notice that the variables in COMMON /CM12/ are REAL, not the default DOUBLE PRECISION.$INFN" FIRST" INCLUDE 'C:\NMVI\SIZES'" COMMON /CM12/ CO
Carlos I'm not sure what you want to do. DruDevo (www.drudevo.com, don't know if they are still around) has a web site that seems to imply they do some of this:Ø
Automated structural
model search
Automated statistical
model search
Automated multi level
covariate search
Ø
Automated m
e looking for, but I really don't
know what that is. As Bill pointed out, PDx-Pop from Icon/globomax may
be your best bet. Mark Sale MD Next Level Solutions, LLC www.NextLevelSolns.com 919-846-9185Mark Sale MDNext Level Solutions, LLCwww.NextLevelSolns.com919-846-9185
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