pretty standard $EST I think $ESTIMATION METH=1 NUMERICAL SLOW LAPLACIAN INTER NOTHETABOUNDTEST NOOMEGABOUNDTEST MAXEVAL=9999 PRINT=1 NOABORT MSFO=MSF1
and just 1. Mark Sale M.D. Vice President, Modeling and Simulation Nuventra Pharma Sciences, Inc. 2525 Meridian Parkway, Suite 280 Durham, NC 27713 Phone (919)-973-0383 ms...@nuventra.com<ms...@kinetigen.com> CONFIDENTIALITY NOTICE The information in this transmittal (including attachments, if any) may be privileged and confidential and is intended only for the recipient(s) listed above. Any review, use, disclosure, distribution or copying of this transmittal, in any form, is prohibited except by or on behalf of the intended recipient(s). If you have received this transmittal in error, please notify me immediately by reply email and destroy all copies of the transmittal. ________________________________ From: Bill Denney <wden...@humanpredictions.com> Sent: Sunday, July 17, 2016 4:54:05 PM To: Mark Sale; nmusers@globomaxnm.com Subject: Re: [NMusers] Laplacian, BQL and initial estimates Hi Mark, Might you have more than one $EST step where Laplacian is not used in one of them? And, can you share your $EST step options? Thanks, Bill On 7/17/2016 4:28 PM, Mark Sale wrote: Question: NONMEM has a function to run a grid search to obtain initial estimates for THETA. But, when I try to do this with BQL data/Laplacian I get this run time error message: 0PROGRAM TERMINATED BY OBJ WITH INDIVIDUAL 1 ID= 1.00000000000000E+00 DATA REC. 13 WITH NMPR17, LAPLACIAN ESTIMATION METHOD MUST BE USED It seems the Laplacian isn't used for the grid search for initial estimates (even though specified in $EST). any ideas? Mark Sale M.D. Vice President, Modeling and Simulation Nuventra Pharma Sciences, Inc. 2525 Meridian Parkway, Suite 280 Durham, NC 27713 Phone (919)-973-0383 ms...@nuventra.com<ms...@kinetigen.com> CONFIDENTIALITY NOTICE The information in this transmittal (including attachments, if any) may be privileged and confidential and is intended only for the recipient(s) listed above. Any review, use, disclosure, distribution or copying of this transmittal, in any form, is prohibited except by or on behalf of the intended recipient(s). If you have received this transmittal in error, please notify me immediately by reply email and destroy all copies of the transmittal. ________________________________ [Human Predictions Logo]<http://www.humanpredictions.com>William S. Denney, PhD Chief Scientist, Human Predictions LLC +1-617-899-8123 wden...@humanpredictions.com<mailto:wden...@humanpredictions.com>
