[NMusers] Time-to-event analysis with $DES

2011-03-23 Thread Hyewon Kim
Dear NMuser I am trying to analyze time to repeated event data using NONMEM. The response were obtained till 24 hours after drug administration. Inhibitory Emax model was implemented. I am getting unreasonable parameter estimates which is far beyond what data say. If some body can point out what i

Re: [NMusers] Time-to-event analysis with $DES

2011-03-24 Thread Hyewon Kim
t; You may also find it easier to develop the model if you do not try to > estimate a random effect on LAMD until you have got reasonable estimates for > the other parameters. > > You may find it helpful to look at this presentation showing how to code > time to event models in NM-