RE: [NMusers] Problem of STS in NONMEM

Hi Anyue, You need to amend MAXEVAL=0 in $EST (I suggest MAXEVAL=) in order to allow estimation. Kind regards, Richard Richard Mills PhD Senior Scientist, PKPDM&S [http://emailsignature/stationary/Icon_Development_Solutions.gif] ICON plc made the following annotations.

Re: [NMusers] Problem of STS in NONMEM

Dear Anyue, It has been a long time since I used this method. Nowadays NONMEM has much added functionality, such as the non-parameteric step and the possibility to repeat problems over individuals in your dataset. My advise would actually be to use those. The latter especially gives you a much cle

RE: [NMusers] Problem of STS in NONMEM

Dear Anyue, I don’t know what you mean by “the individual parameter estimate changed if I change the initial value of THETA” If you mean that individual ETA estimates change, that is expected when you change THETA. For CL and V to be the same, ETA need to change when THETA change. It may be t

Re: [NMusers] Problem of STS in NONMEM

Dear all, Thanks for replying me. I am trying to carry out the first stage of Standard Two Stage estimation method in NONMEM (i.e. estimate individual parameter by ID). For the sake of argument, let's assume that I have a data file which includes 10 subjects (ID from 1 to 10). Now I wish to estim

RE: [NMusers] Problem of STS in NONMEM

Dear Anyue, I think you are trying to make a short-cut to getting individual parameter estimates in one go. It maybe possible for someone more intelligent than me, but can I suggest just doing it the long way round by fitting the model to each individual in turn. Something like this should wo

[NMusers] Nested if

All: I have a control stream that runs okay which involves differential equations. When I requested an output table containing thetas I got this error. , " The characters in error are: Theta 479 This item is not listed in module NMPRD4 and may not be displayed." I have searched the arch

Re: [NMusers] Problem of STS in NONMEM

You may try to remove eta3. As you set it now, you allow very large residual error, and nonmem returns initial estimates as final Leonid > On Dec 22, 2015, at 5:32 AM, Anyue Yin wrote: > > Dear all, > > Thanks for replying me. > > I am trying to carry out the first stage of Standard Two Sta

[NMusers] BAYES method and initial estimate bounds

Hi all, If bounds are specified in the $THETA statements for initial estimates, what, if any, effect do they have when the BAYES method is used? I initially thought they might work in conjunction with the prior specifications to implement truncated priors. However that does not seem to be true be

RE: [NMusers] BAYES method and initial estimate bounds

Bill: I just tested this on a simple script (see below), and the boundaries are imposed in BAYES analysis for me. $PROB RUN# Example 1 (from samp5l) $INPUT C SET ID JID TIME DV=CONC AMT=DOSE RATE EVID MDV CMT CLX V1X QX V2X SDIX SDSX $DATA example1.csv IGNORE=C $SUBROUTINES ADVAN3 TRANS4 $PK MU

[NMusers] Mark Your Calendars! Hold the Dates! ICON NONMEM/PDxPoP Workshops for 2016

The following workshops have been scheduled for 2016: March 1-3 – San Francisco, California – 3-day NONMEM/PDxPoP Workshop Location: Doubletree by Hilton San Francisco Airport, 835 Airport Boulevard, Burlingame, CA 94010 (just 10 minutes from the airport!) March 4 – San Francisco, California –

Re: [NMusers] BAYES method and initial estimate bounds

Hi Bob, Thanks for the reply. On investigating further I see this happens when NONMEM reports a THETA value of 1.34+154 in the PRDERR file. Would I be correct in thinking that is the result of a floating point error somewhere in the sampling process? Thanks, Bill On Tue, Dec 22, 2015 at 12:40 PM

RE: [NMusers] BAYES method and initial estimate bounds

Bill: Yes, and when that happens, the execution path is difficult to anticipate. Robert J. Bauer, Ph.D. Vice President, Pharmacometrics R&D ICON Early Phase Office: (215) 616-6428 Mobile: (925) 286-0769 robert.ba...@iconplc.com www.iconplc.com

RE: [NMusers] BAYES method and initial estimate bounds

1.34+154 is often on many systems used to indicate an improbably large floating point number that is likely an error of some sort. It is the sqrt of the largest representable real*8 value, 1.797+308 From: owner-nmus...@globomaxnm.com [owner-nmus...@globomaxnm.co