Bill: I just tested this on a simple script (see below), and the boundaries are imposed in BAYES analysis for me.
$PROB RUN# Example 1 (from samp5l) $INPUT C SET ID JID TIME DV=CONC AMT=DOSE RATE EVID MDV CMT CLX V1X QX V2X SDIX SDSX $DATA example1.csv IGNORE=C $SUBROUTINES ADVAN3 TRANS4 $PK MU_1=THETA(1) MU_2=THETA(2) MU_3=THETA(3) MU_4=THETA(4) IF (THETA(1)<1.63.OR.THETA(1)>1.8) WRITE(50,*) THETA(1) CL=DEXP(THETA(1)+ETA(1)) V1=DEXP(THETA(2)+ETA(2)) Q=DEXP(MU_3+ETA(3)) V2=DEXP(MU_4+ETA(4)) S1=V1 $ERROR Y = F + F*EPS(1) $THETA (1.63, 1.67,1.8) 2.0 2.0 2.0 $OMEGA BLOCK(4) VALUES(0.15,0.01) $SIGMA (0.6 ) $PRIOR NWPRI $THETAP (2.0 FIX) (2.0 FIX) (2.0 FIX) (2.0 FIX) $THETAPV BLOCK(4) FIX VALUES(10000,0.0) $OMEGAP BLOCK(4) FIX VALUES(0.2,0.0) $OMEGAPD (4 FIX) $EST METHOD=BAYES INTERACTION NITER=1000 PRINT=100 CTYPE=3 $COV MATRIX=R PRINT=E UNCONDITIONAL Robert J. Bauer, Ph.D. Vice President, Pharmacometrics R&D ICON Early Phase Office: (215) 616-6428 Mobile: (925) 286-0769 robert.ba...@iconplc.com<mailto:robert.ba...@iconplc.com> www.iconplc.com<http://www.iconplc.com> From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Bill Gillespie Sent: Tuesday, December 22, 2015 8:14 AM To: nmusers@globomaxnm.com Subject: [NMusers] BAYES method and initial estimate bounds Hi all, If bounds are specified in the $THETA statements for initial estimates, what, if any, effect do they have when the BAYES method is used? I initially thought they might work in conjunction with the prior specifications to implement truncated priors. However that does not seem to be true because statements like "IF(ABS(THETA(1)) > 10) EXIT 1 14" sometimes get tripped even when THETA(1) is bounded between -10 and 10 in the $THETA statement. Happy Holidays, Bill <br /><br /> ICON plc made the following annotations. ------------------------------------------------------------------------------ This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835
